发明授权
US5922724A Benzimidazole compounds and their use as modulators of the GABA a
receptor complex
失效
苯并咪唑化合物及其用作GABA受体复合物的调节剂
- 专利标题: Benzimidazole compounds and their use as modulators of the GABA a receptor complex
- 专利标题(中): 苯并咪唑化合物及其用作GABA受体复合物的调节剂
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申请号: US945023申请日: 1998-02-05
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公开(公告)号: US5922724A公开(公告)日: 1999-07-13
- 发明人: Lene Teuber , Frank Watjen , Yoshimasa Fukuda , Osamu Ushiroda , Toshiro Sasaki
- 申请人: Lene Teuber , Frank Watjen , Yoshimasa Fukuda , Osamu Ushiroda , Toshiro Sasaki
- 申请人地址: DKX Glostrup JPX Tokyo
- 专利权人: Neurosearch A/S,Meiji Seika Kaisha, Ltd.
- 当前专利权人: Neurosearch A/S,Meiji Seika Kaisha, Ltd.
- 当前专利权人地址: DKX Glostrup JPX Tokyo
- 优先权: DKX0460/95 19950421
- 主分类号: C07D401/14
- IPC分类号: C07D401/14 ; A61K31/415 ; A61K31/4184 ; A61K31/44 ; A61K31/4427 ; A61K31/443 ; A61K31/4439 ; A61K31/501 ; A61K31/505 ; A61K31/506 ; A61P25/00 ; A61P25/08 ; A61P25/20 ; A61P25/22 ; A61P25/28 ; A61P43/00 ; C07D235/06 ; C07D401/10 ; C07D403/10 ; C07D403/14 ; C07D405/10 ; C07D405/14 ; C07D409/10 ; C07D413/14 ; C07D417/10 ; C07D417/14 ; C07D521/00 ; A61K31/425
摘要:
The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R.sup.3 is ##STR2## wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH;R.sup.11 is phenyl, benzimidazolyl, or monocyclic heteroaryl all of which may be substituted one or more times with substituents selected from alkyl, alkoxy, phenyl, halogen, CF.sub.3, amino, nitro, cyano, acyl, acylamino, phenyl and monocyclic heteroaryl; andone of R.sup.6 and R.sup.7 is hydrogen and the other is furanyl or isoxazolyl each of which may be substituted one or more times with substituents selected from halogen, alkyl, alkoxy and phenyl. The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
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