发明授权
- 专利标题： Process for preparing biaryl compounds
- 专利标题（中）： 联芳基化合物的制备方法
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申请号： US966335申请日： 1997-11-07
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公开(公告)号： US5922898A公开(公告)日： 1999-07-13
- 发明人: Joseph Arthur Miller , Robert Patrick Farrell
- 申请人： Joseph Arthur Miller , Robert Patrick Farrell
- 申请人地址： CA Mountain View
- 专利权人： Catalytica Pharmaceuticals, Inc.
- 当前专利权人： Catalytica Pharmaceuticals, Inc.
- 当前专利权人地址： CA Mountain View
- 主分类号： C07B49/00
- IPC分类号： C07B49/00 ; C07C45/68 ; C07C67/343 ; C07C253/30 ; C07C255/50 ; C07D213/85 ; C07C45/67 ; C07C69/76 ; C07D213/73
摘要：
The present invention provides a process for preparing biaryl compounds comprising reacting an arylmetal reagent selected from arylmagnesium reagents and aryllithium reagents with an arylhalide in the presence of a catalyst system comprising a catalyst selected from nickel catalysts and palladium catalysts and a cocatalyst selected from zinc cocatalysts and cadmium cocatalysts. The present invention specifically provides a process for the preparation of 2-(4'-methylphenyl)benzonitrile comprising reacting a 4-methylphenylmagnesium reagent with a 2-halobenzonitrile in the presence of a catalyst system comprising a catalyst selected from nickel catalysts and palladium catalysts and a zinc cocatalyst.
公开/授权文献
- US5355362A Digital loop carrier system 公开/授权日：1994-10-11
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