公开(公告)号：US5922898A

公开(公告)日：1999-07-13

申请号：US966335

申请日：1997-11-07

申请人： Joseph Arthur Miller ,  Robert Patrick Farrell

发明人： Joseph Arthur Miller ,  Robert Patrick Farrell

IPC分类号： C07B49/00 ,  C07C45/68 ,  C07C67/343 ,  C07C253/30 ,  C07C255/50 ,  C07D213/85 ,  C07C45/67 ,  C07C69/76 ,  C07D213/73

CPC分类号： C07B49/00 ,  C07C253/30 ,  C07C45/68 ,  C07C67/343 ,  C07D213/85

摘要： The present invention provides a process for preparing biaryl compounds comprising reacting an arylmetal reagent selected from arylmagnesium reagents and aryllithium reagents with an arylhalide in the presence of a catalyst system comprising a catalyst selected from nickel catalysts and palladium catalysts and a cocatalyst selected from zinc cocatalysts and cadmium cocatalysts. The present invention specifically provides a process for the preparation of 2-(4'-methylphenyl)benzonitrile comprising reacting a 4-methylphenylmagnesium reagent with a 2-halobenzonitrile in the presence of a catalyst system comprising a catalyst selected from nickel catalysts and palladium catalysts and a zinc cocatalyst.

摘要翻译： 本发明提供了一种制备联芳基化合物的方法，包括在包含选自镍催化剂和钯催化剂的催化剂和选自锌助催化剂和助催化剂的助催化剂的催化剂体系存在下使选自芳基镁试剂和芳基锂试剂的芳基金属试剂与芳基卤反应， 镉助催化剂 本发明具体提供了制备2-（4'-甲基苯基）苄腈的方法，包括在包含选自镍催化剂和钯催化剂的催化剂的催化剂体系存在下使4-甲基苯基镁试剂与2-卤代苄腈反应， 锌助催化剂。