发明授权
US5925792A Process for preparing 2-amino-1,3-alkanediol or derivative thereof,
process for preparing optically active dihydrosphingosine derivative,
and intermediates for optically active dihydrosphingosine derivative
失效
制备2-氨基-1,3-链烷二醇或其衍生物的方法，制备光学活性二氢鞘氨醇衍生物的方法和光学活性二氢鞘氨醇衍生物的中间体
- 专利标题： Process for preparing 2-amino-1,3-alkanediol or derivative thereof, process for preparing optically active dihydrosphingosine derivative, and intermediates for optically active dihydrosphingosine derivative
- 专利标题（中）： 制备2-氨基-1,3-链烷二醇或其衍生物的方法，制备光学活性二氢鞘氨醇衍生物的方法和光学活性二氢鞘氨醇衍生物的中间体
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申请号： US696161申请日： 1996-08-13
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公开(公告)号： US5925792A公开(公告)日： 1999-07-20
- 发明人: Kazutoshi Sakurai , Kenya Ishida
- 申请人： Kazutoshi Sakurai , Kenya Ishida
- 申请人地址： JPX Tokyo
- 专利权人： Takasago International Corporation
- 当前专利权人： Takasago International Corporation
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX7-239045 19050825
- 主分类号： C07B53/00
- IPC分类号： C07B53/00 ; C07B61/00 ; C07C213/00 ; C07C213/08 ; C07C215/10 ; C07C229/22 ; C07D303/48 ; C07C209/00
摘要：
A process for preparing an optically active dihydrosphingosine derivative is disclosed, comprising reducing a (2R,3R)-2-amino-3-hydroxyalkanoic acid derivative represented by formula (III): ##STR1## wherein R.sup.3 represents a straight-chain alkyl group having 7 to 21 carbon atoms; and R.sup.4 represents an amino group protecting group, (e.g., (2R,3R)-2-benzylamino-3-hydroxyoctadecanoic acid) with sodium tetrahydroborate in the presence of an acid. The process makes it feasible to produce an optically active dihydrosphingosine at high optical purity and through a simple process that is safe and easy to industrialize.
公开/授权文献
- US4614778A Random copolymer 公开/授权日：1986-09-30
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