发明授权
- 专利标题： Huperzine A derivatives, their preparation and their use
- 专利标题（中）： 石杉碱甲衍生物，其制备及其用途
-
申请号： US860524申请日： 1997-06-27
-
公开(公告)号： US5929084A公开(公告)日： 1999-07-27
- 发明人: Dayuan Zhu , Xican Tang , Jinlai Lin , Cheng Zhu , Jingkang Shen , Guansong Wu , Shanhao Jiang , Takuji Yamaguchi , Kazuhiro Tanaka , Takeshi Wakamatsu , Hiroaki Nishimura
- 申请人： Dayuan Zhu , Xican Tang , Jinlai Lin , Cheng Zhu , Jingkang Shen , Guansong Wu , Shanhao Jiang , Takuji Yamaguchi , Kazuhiro Tanaka , Takeshi Wakamatsu , Hiroaki Nishimura
- 申请人地址： CNX Shangahi
- 专利权人： Shangahi Institute of Materia Medica Chinese Academy of Sciences
- 当前专利权人： Shangahi Institute of Materia Medica Chinese Academy of Sciences
- 当前专利权人地址： CNX Shangahi
- 优先权： CHX94114057.1 19941228
- 主分类号： A61K31/435
- IPC分类号： A61K31/435 ; A61K31/439 ; A61K31/44 ; A61K31/4427 ; A61K31/443 ; A61K31/444 ; A61K31/4748 ; A61K36/18 ; A61P21/00 ; A61P25/28 ; C07D221/22 ; C07D401/06 ; C07D401/12 ; C07D401/14 ; C07D405/12 ; C07D221/06
摘要：
The present invention relates to novel huperzine A derivatives of formula (II), wherein Y is ##STR1## or R" and Y together form .dbd.CH; R is (C.sub.1 -C.sub.5) alkyl, ##STR2## wherein n is 0 or 1, X is H, (C.sub.1 -C.sub.5) alkyl; (C.sub.1 -C.sub.5) alkyloxy; nitro, halogen, carboxy, alkyloxycarbonyl, hydroxymethyl, hydroxy, amino substituted by bis-(C.sub.1 -C.sub.5) alkyl; --(CH.sub.2).sub.m COOZ, wherein m=0-5, Z is H or (C.sub.1 -C.sub.5) alkyl; --CH.dbd.CH--G, wherein G is phenyl, furanyl, carboxy, alkyloxycarbonyl; and dihydro- or tetrahydro-pyridyl substituted by (C.sub.1 -C.sub.5) alkyl at the nitrogen atom; R' is H, (C.sub.1 -C.sub.5) alkyl, pyridoyl, benzoyl substituted by (C.sub.1 -C.sub.5) alkyloxy; R" is H or (C.sub.1 -C.sub.5) alkyl; processes for their use as acetylcholinesterase inhibitor. ##STR3##