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公开(公告)号:US5929084A
公开(公告)日:1999-07-27
申请号:US860524
申请日:1997-06-27
申请人: Dayuan Zhu , Xican Tang , Jinlai Lin , Cheng Zhu , Jingkang Shen , Guansong Wu , Shanhao Jiang , Takuji Yamaguchi , Kazuhiro Tanaka , Takeshi Wakamatsu , Hiroaki Nishimura
发明人: Dayuan Zhu , Xican Tang , Jinlai Lin , Cheng Zhu , Jingkang Shen , Guansong Wu , Shanhao Jiang , Takuji Yamaguchi , Kazuhiro Tanaka , Takeshi Wakamatsu , Hiroaki Nishimura
IPC分类号: A61K31/435 , A61K31/439 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4748 , A61K36/18 , A61P21/00 , A61P25/28 , C07D221/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D221/06
CPC分类号: C07D401/06 , C07D221/22 , C07D401/12 , C07D401/14 , C07D405/12
摘要: The present invention relates to novel huperzine A derivatives of formula (II), wherein Y is ##STR1## or R" and Y together form .dbd.CH; R is (C.sub.1 -C.sub.5) alkyl, ##STR2## wherein n is 0 or 1, X is H, (C.sub.1 -C.sub.5) alkyl; (C.sub.1 -C.sub.5) alkyloxy; nitro, halogen, carboxy, alkyloxycarbonyl, hydroxymethyl, hydroxy, amino substituted by bis-(C.sub.1 -C.sub.5) alkyl; --(CH.sub.2).sub.m COOZ, wherein m=0-5, Z is H or (C.sub.1 -C.sub.5) alkyl; --CH.dbd.CH--G, wherein G is phenyl, furanyl, carboxy, alkyloxycarbonyl; and dihydro- or tetrahydro-pyridyl substituted by (C.sub.1 -C.sub.5) alkyl at the nitrogen atom; R' is H, (C.sub.1 -C.sub.5) alkyl, pyridoyl, benzoyl substituted by (C.sub.1 -C.sub.5) alkyloxy; R" is H or (C.sub.1 -C.sub.5) alkyl; processes for their use as acetylcholinesterase inhibitor. ##STR3##
摘要翻译: PCT No.PCT / CN95 / 00100 Sec。 371日期:1997年6月27日 102(e)日期1997年6月27日PCT提交1995年12月26日PCT公布。 公开号WO96 / 20176 日期:1996年7月4日本发明涉及式(Ⅱ)的新型石杉碱甲衍生物,其中Y为或R“和Y一起形成= CH; R为(C 1 -C 5)烷基,其中n为0或1,X为H,(C 1 -C 5)烷基; (C1-C5)烷氧基; 硝基,卤素,羧基,烷氧基羰基,羟甲基,羟基,被双 - (C 1 -C 5)烷基取代的氨基; - (CH 2)m COOZ,其中m = 0-5,Z是H或(C 1 -C 5)烷基; -CH = CH-G,其中G是苯基,呋喃基,羧基,烷氧基羰基; 在氮原子被(C 1 -C 5)烷基取代的二氢或四氢吡啶基; R'是H,(C1-C5)烷基,吡啶基,(C1-C5)烷氧基取代的苯甲酰基; R“是H或(C 1 -C 5)烷基; 它们用作乙酰胆碱酯酶抑制剂的方法。
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公开(公告)号:US20220273598A1
公开(公告)日:2022-09-01
申请号:US17631804
申请日:2020-08-05
申请人: SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. , SHANGAHI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
发明人: Meiyu Geng , Guangqiang Sun , Xinyi Wang , Jing Zhang , Teng Feng
IPC分类号: A61K31/198 , A61K31/437 , A61K31/702 , A61P25/28 , G01N33/483 , G01N33/50 , G01N33/68
摘要: Provided is the use of a reagent for inhibiting the uptake of amino acids by naive T cells in the preparation of a drug for treating Alzheimer's disease in a subject.
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