- 专利标题： Inhibitors of IMPDH enzyme
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申请号： US816764申请日： 1997-03-14
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公开(公告)号： US5932600A公开(公告)日： 1999-08-03
- 发明人: Jeffrey O. Saunders , David M. Armistead , Michael C. Badia , Randy S. Bethiel , Catharine A. Frank , Doug Naegele , Perry M. Novak , David A. Pearlman , Steven M. Ronkin
- 申请人： Jeffrey O. Saunders , David M. Armistead , Michael C. Badia , Randy S. Bethiel , Catharine A. Frank , Doug Naegele , Perry M. Novak , David A. Pearlman , Steven M. Ronkin
- 申请人地址： MA Cambridge
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： MA Cambridge
- 主分类号： A61K31/4184
- IPC分类号： A61K31/4184 ; A61K31/423 ; A61K31/428 ; C07D235/30 ; C07D263/58 ; C07D413/12 ; C07D417/12 ; A61K31/425 ; A61K31/42
摘要：
The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
公开/授权文献
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