发明授权
- 专利标题: N-aminoalkylfluorenecarboxamides
- 专利标题(中): N-氨基烷基芴甲酰胺
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申请号: US908361申请日: 1997-08-07
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公开(公告)号: US5932734A公开(公告)日: 1999-08-03
- 发明人: Jun Yuan , Xi Chen
- 申请人: Jun Yuan , Xi Chen
- 申请人地址: CT Branford
- 专利权人: Neurogen Corporation
- 当前专利权人: Neurogen Corporation
- 当前专利权人地址: CT Branford
- 主分类号: C07D295/12
- IPC分类号: C07D295/12 ; A61K31/00 ; A61K31/38 ; A61K31/381 ; A61K31/445 ; A61K31/451 ; A61K31/495 ; A61K31/496 ; A61P25/00 ; A61P25/18 ; A61P25/24 ; A61P25/26 ; A61P25/28 ; A61P43/00 ; C07D211/14 ; C07D211/18 ; C07D211/32 ; C07D211/70 ; C07D217/02 ; C07D217/04 ; C07D295/13 ; C07D333/20 ; C07D333/34 ; C07D295/15
摘要:
Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein: G represents a group of the formula ##STR2## where R.sub.a and R.sub.b represent hydrogen, or organic or inorganic substituents;A is an optionally substituted alkylene;R.sub.1, R.sub.2, R.sub.3, R.sub.4 represent organic or inorganic substituents;R.sub.5 is hydrogen or lower alkyl;R.sub.6 and R.sub.7 independently represent hydrogen, lower alkyl; or together form a ring of 5-8 members;Z is nitrogen or carbon; andW is optionally substituted aryl or heteroaryl. Compounds of the present invention demonstrate high affinity and selectivity in binding to the D.sub.3 receptor subtype.
公开/授权文献
- USD350868S Single hopper coffee bean grinder and brewer 公开/授权日:1994-09-27
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