- 专利标题： Inhibitors of farnesyl-protein transferase
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申请号： US823919申请日： 1997-03-25
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公开(公告)号： US5939557A公开(公告)日： 1999-08-17
- 发明人: Neville J. Anthony , Robert P. Gomez , Kelly M. Solinsky
- 申请人： Neville J. Anthony , Robert P. Gomez , Kelly M. Solinsky
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： C07D233/54
- IPC分类号： C07D233/54 ; C07D233/70 ; C07D401/14 ; C07D403/10 ; C07D403/14 ; C07D409/10 ; C07D409/14 ; C07D413/06 ; C07D417/06 ; C07D417/10 ; C07D417/14
摘要：
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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