Centrifuges having a rotating bowl and associated computerized systems for monitoring, diagnosing, operating and controlling various parameters and processes of the centrifuges are presented. The computerized control system actuates at least one out of a plurality of control devices based on input from one or more monitoring sensors so as to provide real time continuous operational control. The monitoring sensors may sense process and other parameters and may be located both inside the centrifuge or bowl and outside the centrifuge or bowl and may monitor machine operation parameters and parameters related to the input and output streams of the centrifuge.