发明授权
- 专利标题： 2R,4S,R, S- and 2S,4R,R,S-hydroxyitraconazole
- 专利标题（中）： 2R，4S，R，S-和2S，4R，R，S-羟基特他康唑
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申请号： US968780申请日： 1997-11-12
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公开(公告)号： US5952502A公开(公告)日： 1999-09-14
- 发明人: John R. McCullough , Chris H. Senanayake , Gerald J. Tanoury , Yaping Hong , Patrick Koch
- 申请人： John R. McCullough , Chris H. Senanayake , Gerald J. Tanoury , Yaping Hong , Patrick Koch
- 申请人地址： MA Marlborough
- 专利权人： Sepracor Inc.
- 当前专利权人： Sepracor Inc.
- 当前专利权人地址： MA Marlborough
- 主分类号： A61K31/4196
- IPC分类号： A61K31/4196 ; A61P31/10 ; C07D249/12 ; C07D405/06 ; C07D405/14 ; C07D521/00 ; C07D413/00
摘要：
A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl (R,S)-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceutical compositions containing these compounds and to their use for the treatment of fungal infection are also disclosed.
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