发明授权
- 专利标题: Process for the simultaneous production of artemisnin and essential oil from the plant artemisia annua
- 专利标题(中): 从青蒿中同时生产青蒿素和精油的方法
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申请号: US944865申请日: 1997-10-06
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公开(公告)号: US5955084A公开(公告)日: 1999-09-21
- 发明人: Dharam Chand Jain , Sudeep Tandon , Rajendra Singh Bhakuni , Mohammed Shafique Siddique , Atul Prakash Kahol , Ram Prakash Sharma , Sushil Kumar , Asish Kumar Bhattacharya
- 申请人: Dharam Chand Jain , Sudeep Tandon , Rajendra Singh Bhakuni , Mohammed Shafique Siddique , Atul Prakash Kahol , Ram Prakash Sharma , Sushil Kumar , Asish Kumar Bhattacharya
- 专利权人: Council of Scientific and Industrial Research (CSIR)
- 当前专利权人: Council of Scientific and Industrial Research (CSIR)
- 优先权: INX652/DEL/97 19970317
- 主分类号: A61K36/00
- IPC分类号: A61K36/00 ; A61K36/282 ; C07C51/48 ; C07C57/26 ; C07D493/18 ; C07D493/20 ; C11B5/00 ; C11B9/02 ; C11B13/00 ; A61K35/78
摘要:
This invention relates to a novel process for the dual production of essential oil and artemisinin from the plant Artemisia annua, said process comprising extracting the plant with hexane, partitioning the hexane extract between hexane and acetonitrile, hydrodistillation of hexane residue and Marc to yield essential oil, further fractionation of acetonitrile solvent between hexane-benzene mixture to remove artemisinic acid, chromatographing of the acetonitrile phase to produce substantially pure artemisinin, the artemisinic acid is reduced to obtain dihydro artemisinic acid which is then oxidised in a single step to form artemisinin.
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