发明授权
US5955354A RAS P21-interacting protein (RGL) and its RAS interacting domain (RID)
失效
RAS P21相互作用蛋白（RGL）及其RAS相互作用域（RID）
- 专利标题： RAS P21-interacting protein (RGL) and its RAS interacting domain (RID)
- 专利标题（中）： RAS P21相互作用蛋白（RGL）及其RAS相互作用域（RID）
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申请号： US408519申请日： 1995-03-20
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公开(公告)号： US5955354A公开(公告)日： 1999-09-21
- 发明人: Lewis T. Williams , Susan Demo
- 申请人： Lewis T. Williams , Susan Demo
- 申请人地址： CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： CA Oakland
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/47 ; C07H21/04 ; A61K38/17 ; C12N15/63 ; C12N15/79
摘要：
A novel protein which interacts with ras p21, has been identified. This protein, RGL, shares 69% amino acid homology with ral guanine nucleotide dissociation stimulator (ralGDS). ralGDS was also found to bind ras p21. The ras p21-interacting domain of RGL (RID) bound to ras p21 through the effector loop of ras p21. Polypeptide and polynucleotide compositions of the RGL protein are provided as well as methods for implementing the diagnostic and therapeutic uses of these compositions. The uses include isolating effector proteins of ras p21 and modulating ras activity.
公开/授权文献
- US5122966A Computer generated tool path interference check method 公开/授权日：1992-06-16
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