发明授权
US5955635A Process for the preparation of 4-(6'-methoxy-2'-naphthyl) butan-2-one
失效
4-（6'-甲氧基-2'-萘基）丁-2-酮的制备方法
- 专利标题： Process for the preparation of 4-(6'-methoxy-2'-naphthyl) butan-2-one
- 专利标题（中）： 4-（6'-甲氧基-2'-萘基）丁-2-酮的制备方法
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申请号： US065972申请日： 1998-04-24
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公开(公告)号： US5955635A公开(公告)日： 1999-09-21
- 发明人: Walter Cabri , Domenico Magrone , Roberto Angelini , Erminio Oldani
- 申请人： Walter Cabri , Domenico Magrone , Roberto Angelini , Erminio Oldani
- 申请人地址： ITX Baranzate di Bollate
- 专利权人： Secifarma S.P.A.
- 当前专利权人： Secifarma S.P.A.
- 当前专利权人地址： ITX Baranzate di Bollate
- 优先权： ITXMI97A1006 19970430
- 主分类号： C07C45/67
- IPC分类号： C07C45/67 ; C07C49/255 ; C07C67/343 ; C07C45/45
摘要：
An improved process for the preparation of Nabumetone, which comprises the following steps:a) condensation between 6-methoxy-naphthaldehyde I and t-butyl acetoacetate II, to give 3-t-butoxycarbonyl-4-(6'-methoxy-2'-naphthyl)-but-3-en-2-one III as an E/Z mixture;b) hydrogenation of III in the presence of a palladium catalyst, to give 3-t-butoxycarbonyl-4-(6'-methoxy-2-naphthyl)-butan-2-one IV;c) cleavage of the t-butyl ester by acid catalysis; andd) recrystallization of the crude with methanol.
公开/授权文献
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