发明授权
- 专利标题: In vivo binding pair pretargeting
- 专利标题(中): 体内结合对预靶向
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申请号: US461267申请日: 1995-06-05
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公开(公告)号: US5965106A公开(公告)日: 1999-10-12
- 发明人: Nicholas Pomato , Richard P. McCabe , Gregory A. Hawkins , Reinhard Bredehorst , Chong-Ho Kim , Carl-Wilhelm Vogel
- 申请人: Nicholas Pomato , Richard P. McCabe , Gregory A. Hawkins , Reinhard Bredehorst , Chong-Ho Kim , Carl-Wilhelm Vogel
- 申请人地址: MD Rockville
- 专利权人: PerImmune Holdings, Inc.
- 当前专利权人: PerImmune Holdings, Inc.
- 当前专利权人地址: MD Rockville
- 主分类号: A61K47/48
- IPC分类号: A61K47/48 ; A61K51/10 ; A61K39/395 ; A61K51/00
摘要:
A method for in-vivo targeting a functional moiety in a patient by administering a targeting moiety coupled to an affinity component, wherein the targeting moiety has affinity for binding sites in a target area, and administering a binding partner to the affinity component coupled to a functional moiety to localize the functional moiety in the target area. Preferably the targeting moiety is an antibody and the functional moiety is a radiometal when performing in vivo imaging or therapy. The affinity component may be a novel methotrexate analog. Preferably, the affinity component is thermo-stabilized.