Invention Grant
- Patent Title: Self-assembling multimeric nucleic acid constructs
- Patent Title (中): 自组装多聚体核酸构建体
-
Application No.: US967297Application Date: 1997-11-07
-
Publication No.: US5965133APublication Date: 1999-10-12
- Inventor: Charles R. Cantor , Christof M. Niemeyer , Cassandra L. Smith , Takeshi Sano , Donald J. Hnatowich , Mary Rusckowski
- Applicant: Charles R. Cantor , Christof M. Niemeyer , Cassandra L. Smith , Takeshi Sano , Donald J. Hnatowich , Mary Rusckowski
- Applicant Address: MA Boston MA Worcester
- Assignee: Trustees of Boston University,Univ. of Mass. Medical Center
- Current Assignee: Trustees of Boston University,Univ. of Mass. Medical Center
- Current Assignee Address: MA Boston MA Worcester
- Main IPC: G01N33/566
- IPC: G01N33/566 ; A61K38/00 ; A61K38/16 ; A61K38/21 ; A61K38/22 ; A61K38/27 ; A61K38/43 ; A61K39/00 ; A61K39/395 ; A61K45/00 ; A61K47/48 ; A61K49/00 ; A61K51/00 ; A61K51/12 ; A61P31/04 ; A61P31/12 ; A61P35/00 ; A61P35/02 ; C03C17/30 ; C03C17/34 ; C07H21/04 ; C12N15/09 ; C12Q1/68 ; A61K31/70
Abstract:
The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products.
Public/Granted literature
- US5303581A Method of and an apparatus for detecting a fault in a return system Public/Granted day:1994-04-19
Information query
IPC分类: