发明授权
US5968946A Heterocyclic derivatives useful in treating central nervous system
disorders
有权
用于治疗中枢神经系统疾病的新型杂环衍生物
- 专利标题： Heterocyclic derivatives useful in treating central nervous system disorders
- 专利标题（中）： 用于治疗中枢神经系统疾病的新型杂环衍生物
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申请号： US166327申请日： 1998-10-05
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公开(公告)号： US5968946A公开(公告)日： 1999-10-19
- 发明人: Bruce E. Maryanoff , David McComsey , James J. McNally , Samuel O. Nortey , Allen B. Reitz
- 申请人： Bruce E. Maryanoff , David McComsey , James J. McNally , Samuel O. Nortey , Allen B. Reitz
- 申请人地址： NJ Raritaon
- 专利权人： Ortho-McNeil Pharmaceutical, Inc.
- 当前专利权人： Ortho-McNeil Pharmaceutical, Inc.
- 当前专利权人地址： NJ Raritaon
- 主分类号： A61K31/4375
- IPC分类号： A61K31/4375 ; A61P25/00 ; A61P25/08 ; A61P25/22 ; C07D471/14 ; A61K31/44
摘要：
This invention relates to a series of substituted 3-oxo-pyrrolo[1,2-a]imidazopyridine derivatives of the formula 1 ##STR1## where X.sub.1 -X.sub.4, R.sub.1, R.sub.2 and Ar are defined herein. In addition the invention relates to pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are ligands for the benzodiazepine site on the GABA-A receptor and display anxiolytic and anticonvulsant activity in animal models.
公开/授权文献
- US4337461A Volume control mechanism for a bell assembly 公开/授权日：1982-06-29
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