发明授权
- 专利标题: Steroids with radical-attracting aromatic substituents, process for the production thereof and pharmaceutical compounds containing the said substances
- 专利标题(中): 具有自由基吸引芳族取代基的类固醇,其制备方法和含有所述物质的药物化合物
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申请号: US253650申请日: 1999-02-20
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公开(公告)号: US5977096A公开(公告)日: 1999-11-02
- 发明人: Peter Droescher , Bernd Menzenbach , Kurt Ponsold , Bernd Undeutsch , Michael Oettel , Wolfgang Romer , Gunter Kaufmann , Jens Schroder
- 申请人: Peter Droescher , Bernd Menzenbach , Kurt Ponsold , Bernd Undeutsch , Michael Oettel , Wolfgang Romer , Gunter Kaufmann , Jens Schroder
- 申请人地址: DEX Jena
- 专利权人: Jenapharm GmbH & Co. KG
- 当前专利权人: Jenapharm GmbH & Co. KG
- 当前专利权人地址: DEX Jena
- 优先权: DEX4338316 19931110
- 主分类号: A61K31/56
- IPC分类号: A61K31/56 ; A61P29/00 ; C07J1/00 ; C07J31/00 ; C07J41/00 ; C07J51/00 ; C07J3/00 ; C07J53/00
摘要:
Novel substituted steroid compounds are disclosed which are more effective than known radical-trapping agents in methods of prophylaxis and therapy of radical-mediated cell damage and of treatment of diseases due to radical-mediated cell damage. The novel substituted steroid compounds can be made from steroids having an estrane, androstane, pregnane or cholestane basic skeleton and have a radical-attracting aromatic substituent of the general formula --(CH.sub.2).sub.n X, or .dbd.CH--(CH.sub.2).sub.m X at the 17 or 6 position of the steroid nucleus, wherein X=Y, OY, SY, SeY or NHY; n=0 to 5; m=n-1 and Y is a phenyl group having five substituents A, B, C, D and E, wherein A to E is independently H, alkyl, Oalkyl, Oacyl, OH, or one of the substituents B, C or D is NR.sub.2 wherein R=alkyl and each of the other substituents is hydrogen. Pharmaceutical compositions containing the novel substituted steroid compounds and methods of making them are also part of the invention.
公开/授权文献
- USRE31462E Electrical connector 公开/授权日:1983-12-13