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公开(公告)号：US20240294567A1
公开(公告)日：2024-09-05
申请号：US18581998
申请日：2024-02-20
申请人： Metselex, Inc.
CPC分类号： C07J9/005 , A61K31/025 , C07J41/0061 , C07J51/00 , C07J63/008 , B01J37/26 , C07C2603/52
摘要： The present invention relates to fluorinated and alkylated bile acids.
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公开(公告)号：US11958879B2
公开(公告)日：2024-04-16
申请号：US17324464
申请日：2021-05-19
发明人： Guoqiang Wang , Yat Sun Or , Ruichao Shen , Xuechao Xing , Jiang Long , Peng Dai , Brett Granger , Jing He
CPC分类号： C07J43/003 , C07J41/005 , C07J41/0055 , C07J41/0088 , C07J9/00 , C07J9/005 , C07J51/00
摘要： The present invention provides compounds represented by Formula I, or pharmaceutically acceptable salts, stereoisomers, solvates, hydrates or combination thereof,
The invention also provides pharmaceutical compositions comprising these compounds and methods of using this compounds for treating FXR-mediated or TGR5-mediated diseases or conditions.-
公开(公告)号：US11725025B2
公开(公告)日：2023-08-15
申请号：US17360614
申请日：2021-06-28
申请人： EMORY UNIVERSITY
发明人： David Brian Guthrie , Mark Andrew Lockwood , Michael G. Natchus , Dennis C. Liotta , Donald G. Stein , Iqbal Sayeed
CPC分类号： C07J41/0016 , A61K31/57 , A61K31/58 , A61K31/661 , A61K45/06 , C07J41/005 , C07J43/003 , C07J51/00 , Y02A50/30 , A61K31/57 , A61K2300/00 , A61K31/661 , A61K2300/00
摘要： This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation such as those resulting from traumatic brain injury or stroke.
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公开(公告)号：US11718641B2
公开(公告)日：2023-08-08
申请号：US17186447
申请日：2021-02-26
发明人： Guoqiang Wang , Yat Sun Or , Ruichao Shen , Jiang Long , Peng Dai , Xuechao Xing , Jing He
CPC分类号： C07J41/0066 , C07J41/0055 , C07J41/0088 , C07J43/003 , C07J43/006 , C07J9/005 , C07J41/0094 , C07J51/00
摘要： The present invention provides compounds of Formula I,
pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.-
公开(公告)号：US20220402966A1
公开(公告)日：2022-12-22
申请号：US17324464
申请日：2021-05-19
发明人： Guoqiang Wang , Yat Sun Or , Ruichao Shen , Xuechao Xing , Jiang Long , Peng Dai , Brett Granger , Jing He
摘要： The present invention provides compounds represented by Formula I, or pharmaceutically acceptable salts, stereoisomers, solvates, hydrates or combination thereof, The invention also provides pharmaceutical compositions comprising these compounds and methods of using this compounds for treating FXR-mediated or TGR5-mediated diseases or conditions.
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公开(公告)号：US20220339164A1
公开(公告)日：2022-10-27
申请号：US17696605
申请日：2022-03-16
发明人： Xiangping QIAN
摘要： Chemical entities that are bufalin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
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公开(公告)号：US20210395293A1
公开(公告)日：2021-12-23
申请号：US17142870
申请日：2021-01-06
发明人： André STEINER , Heidi WAENERLUND POULSEN , Emilie JOLIBOIS , Melissa REWOLINSKI , Ralf GROSS , Emma SHARP , Fiona DUBAS-FISHER , Alex EBERLIN
IPC分类号： C07J9/00 , A61K9/20 , C07J51/00 , A61K31/575
摘要： The present invention relates to obeticholic acid: or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid is useful for the treatment or prevention of a FXR mediated disease or condition, cardiovascular disease or cholestatic liver disease, and for reducing HDL cholesterol, for lowering triglycerides in a mammal, or for inhibition of fibrosis. The present invention also relates to processes for the synthesis of obeticholic acid.
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公开(公告)号：US11053274B2
公开(公告)日：2021-07-06
申请号：US14122872
申请日：2012-06-01
申请人： Jean-Claude Pascal
发明人： Jean-Claude Pascal
摘要： The present invention relates to a process for the preparation of a compound of formula (I) said process comprising the steps of: a) reacting a compound of formula (II), with an acylating or a silylating agent to produce a compound of formula (III), wherein P1 and P2 are each independently a protecting group selected from R2—Si—R3R4, or R1CO—, wherein R1 is a group selected from C1-6alkyl or C3-6cycloalkyl, each group being optionally substituted by one or more substituents independently selected from fluoro or C1-4alkyl; R2, R3 and R4 are each independently a group selected from C1-6alkyl or phenyl, each group being optionally substituted by one or more substituents independently selected from fluoro or C1-4alkyl; b) reacting the compound of formula (III) in the presence of palladium acetate or a derivative thereof to produce compound of formula (IV); and c) reacting the compound of formula (IV) with a reducing agent to produce compound of formula (I).
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公开(公告)号：US20210188897A1
公开(公告)日：2021-06-24
申请号：US17099568
申请日：2020-11-16
发明人： Qian Chen , Guidong Zhu , Hongyu Zhao
摘要： The invention provides novel neuroactive steroids and pharmaceutical compositions thereof, as well as methods of their preparation and use, in therapy of various diseases and conditions, for example, various neurological or brain diseases.
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公开(公告)号：US11040998B2
公开(公告)日：2021-06-22
申请号：US16593262
申请日：2019-10-04
发明人： Guoqiang Wang , Yat Sun Or , Ruichao Shen , Xuechao Xing , Jiang Long , Peng Dai , Brett Granger , Jing He
摘要： The present invention provides compounds represented by Formula I, or pharmaceutically acceptable salts, stereoisomers, solvates, hydrates or combination thereof, The invention also provides pharmaceutical compositions comprising these compounds and methods of using this compounds for treating FXR-mediated or TGR5-mediated diseases or conditions.
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