- 专利标题： Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
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申请号： US833203申请日： 1997-04-14
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公开(公告)号： US5977326A公开(公告)日： 1999-11-02
- 发明人: Feodor Scheinmann , Simon Joel , Andrew V. Stachulski
- 申请人： Feodor Scheinmann , Simon Joel , Andrew V. Stachulski
- 申请人地址： GBX Manchester
- 专利权人： Salford Ultrafine Chemicals and Research Limited
- 当前专利权人： Salford Ultrafine Chemicals and Research Limited
- 当前专利权人地址： GBX Manchester
- 优先权： GBX9116909 19910806; GBX9325065 19931207
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; C07D471/00 ; C07G3/00 ; C07H15/24
摘要：
##STR1## Morphine-6-glucuronide or substituted morphine-6-glucuronide of formulae (I) is made by conjugation of a glucuronate ester and/or substituted glucuronate ester with morphine or substituted morphine in the presence of a Lewis acid catalyst and in the absence of silver catalysts and barium hydroxide and other heavy metal derivatives.
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