公开(公告)号：US5977326A

公开(公告)日：1999-11-02

申请号：US833203

申请日：1997-04-14

申请人： Feodor Scheinmann ,  Simon Joel ,  Andrew V. Stachulski

发明人： Feodor Scheinmann ,  Simon Joel ,  Andrew V. Stachulski

IPC分类号： A61K31/70 ,  C07D471/00 ,  C07G3/00 ,  C07H15/24

CPC分类号： A61K31/70 ,  C07D471/00 ,  C07G3/00 ,  C07H15/24

摘要： ##STR1## Morphine-6-glucuronide or substituted morphine-6-glucuronide of formulae (I) is made by conjugation of a glucuronate ester and/or substituted glucuronate ester with morphine or substituted morphine in the presence of a Lewis acid catalyst and in the absence of silver catalysts and barium hydroxide and other heavy metal derivatives.

公开(公告)号：US4954489A

公开(公告)日：1990-09-04

申请号：US333554

申请日：1989-04-05

申请人： Roger J. Ponsford ,  Andrew V. Stachulski

发明人： Roger J. Ponsford ,  Andrew V. Stachulski

IPC分类号： C07D499/00 ,  C07D499/46 ,  C07D499/58

CPC分类号： C07D499/00 ,  Y02P20/55

摘要： Compounds of formula (I) and their salts and esters: ##STR1## wherein X is hydrogen or a group NHR.sup.1, wherein R.sup.1 is hydrogen or an amino protecting group, and R is optionally substituted C.sub.5-8 cycloalkyl or cycloalkenyl, are useful in the treatment of bacterial infections.

公开(公告)号：US5126335A

公开(公告)日：1992-06-30

申请号：US496777

申请日：1990-03-21

申请人： Roger J. Ponsford ,  Andrew V. Stachulski

发明人： Roger J. Ponsford ,  Andrew V. Stachulski

IPC分类号： C07D499/00 ,  C07D499/46

CPC分类号： C07D499/00 ,  Y02P20/55

摘要： Compounds of formula (I) and pharmaceutically acceptable salts and in-vivo hydrolysable esters thereof: ##STR1## wherein X is hydrogen or a group NHR.sup.1, wherein R.sup.1 is hydrogen or an amino protecting group, and R is an optionally substituted 5-membered or 6-membered saturated heterocyclic group containing 1 or 2 heteroatoms selected from oxygen, sulphur or nitrogen, are useful in the treatment of bacterial infections in humans and animals.