发明授权
- 专利标题： Physically stable solid form of a fluoroquinolone
- 专利标题（中）： 物理稳定的氟喹诺酮固体形式
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申请号： US641569申请日： 1996-05-01
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公开(公告)号： US5985893A公开(公告)日： 1999-11-16
- 发明人: Xuanqiang Yu , William C. Schinzer , Michael J. Dunn , Robert Shih-Liang Chao , Dale S. Aldrich , Azhwarsamy Jeganathan , Michael S. Bergren
- 申请人： Xuanqiang Yu , William C. Schinzer , Michael J. Dunn , Robert Shih-Liang Chao , Dale S. Aldrich , Azhwarsamy Jeganathan , Michael S. Bergren
- 申请人地址： MI Kalamazoo
- 专利权人： Pharmacia & Upjohn Company
- 当前专利权人： Pharmacia & Upjohn Company
- 当前专利权人地址： MI Kalamazoo
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; A61K31/4427 ; A61P31/04 ; C07D401/04 ; A61K31/47 ; C07D215/56
摘要：
Novel crystal forms of the fluoroquinolone, [S-(R*,S*)]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-[1-(methylamino)ethyl]-1-pyrrolidinyl]-4-oxo-3-quinolinecarboxylic acid are disclosed. The forms are characterized by one methanol solvate form, and three anhydrous polymorphic forms, of which, Form III exhibits greatest stability and decreased hygroscopicity.
公开/授权文献
- USD342344S Electric shaver 公开/授权日：1993-12-14
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