发明授权
US5985917A Mercapto and seleno derivatives as inhibitors of nitric oxide synthase
失效
巯基和硒代衍生物作为一氧化氮合酶的抑制剂
- 专利标题： Mercapto and seleno derivatives as inhibitors of nitric oxide synthase
- 专利标题（中）： 巯基和硒代衍生物作为一氧化氮合酶的抑制剂
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申请号： US281125申请日： 1999-03-29
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公开(公告)号： US5985917A公开(公告)日： 1999-11-16
- 发明人: Garry J. Southan , Andrew L. Salzman , Csaba Szabo
- 申请人： Garry J. Southan , Andrew L. Salzman , Csaba Szabo
- 申请人地址： OH Cincinnati
- 专利权人： Children's Hospital Medical Center
- 当前专利权人： Children's Hospital Medical Center
- 当前专利权人地址： OH Cincinnati
- 主分类号： C07D295/20
- IPC分类号： C07D295/20 ; A61K31/095 ; A61K31/155 ; A61K31/195 ; A61K31/198 ; A61K31/425 ; A61K31/426 ; A61K31/54 ; A61P1/00 ; A61P1/02 ; A61P1/16 ; A61P3/08 ; A61P9/10 ; A61P11/00 ; A61P13/02 ; A61P15/00 ; A61P25/28 ; A61P29/00 ; A61P35/00 ; A61P37/00 ; A61P43/00 ; C07C279/14 ; C07C279/34 ; C07C323/25 ; A61K31/28 ; A61K31/31 ; A61K31/33
摘要：
This invention is directed to a pharmacologically acceptable composition for inhibiting nitric oxide synthase in a mammal, which includes a mercapto or seleno derivative and a pharmaceutically acceptable carrier. The invention also concerns a method of inhibiting nitric oxide synthase, selectively inhibiting the inducible isoform of nitric oxide synthase, and treating various conditions where there is an advantage in inhibiting nitric oxide biosynthesis. The method includes the step of administering to a mammal a mercapto or seleno derivative in pure form or in a pharmaceutically acceptable carrier.
公开/授权文献
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