- 专利标题： Expression of pace in host cells and methods of use thereof
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申请号： US480382申请日： 1995-06-07
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公开(公告)号： US5986079A公开(公告)日： 1999-11-16
- 发明人: Philip J. Barr , Anthony J. Brake , Randal J. Kaufman , Patricia Tekamp-Olson , Louise Wasley , Polly A. Wong
- 申请人： Philip J. Barr , Anthony J. Brake , Randal J. Kaufman , Patricia Tekamp-Olson , Louise Wasley , Polly A. Wong
- 申请人地址： MA Cambridge CA Emeryville
- 专利权人： Genetics Institute, Inc.,Chiron Corporation
- 当前专利权人： Genetics Institute, Inc.,Chiron Corporation
- 当前专利权人地址： MA Cambridge CA Emeryville
- 主分类号： C12N5/10
- IPC分类号： C12N5/10 ; C07K14/755 ; C12N9/50 ; C12N9/64 ; C12N15/09 ; C12N15/57 ; C12P21/02 ; C12N15/79 ; C12N15/85
摘要：
Compositions and methods are provided for endopeptidase production and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides, including proteins requiring gamma-carboxylation for biological activity. These compositions and methods utilize recombinant PACE, a mammalian endopeptidase that is specific for dibasic amino acid sites.
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