发明授权
US5986115A 7.alpha.-(.xi.-aminoalkyl)-estratrienes, process for their production,
pharmaceutical preparations which contain these
7.alpha.-(.xi.-aminoalkyl)-estratrienes as well as their use for the
production of pharmaceutical agents
失效
7α-（xi-氨基烷基） - 雌三烯，其制备方法，含有这些7α-（xi-氨基烷基） - 雌三烯的药物制剂及其用于生产药剂
- 专利标题： 7.alpha.-(.xi.-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7.alpha.-(.xi.-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents
- 专利标题（中）： 7α-（xi-氨基烷基） - 雌三烯，其制备方法，含有这些7α-（xi-氨基烷基） - 雌三烯的药物制剂及其用于生产药剂
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申请号： US239490申请日： 1999-01-28
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公开(公告)号： US5986115A公开(公告)日： 1999-11-16
- 发明人: Rolf Bohlmann , Dieter Bittler , Josef Heindl , Nikolaus Heinrich , Helmut Hofmeister , Hermann Kunzer , Gerhard Sauer , Christa Hegele-Hartung , Rosemarie Lichtner , Yukishige Nishino , Karsten Parczyk , Martin Schneider
- 申请人： Rolf Bohlmann , Dieter Bittler , Josef Heindl , Nikolaus Heinrich , Helmut Hofmeister , Hermann Kunzer , Gerhard Sauer , Christa Hegele-Hartung , Rosemarie Lichtner , Yukishige Nishino , Karsten Parczyk , Martin Schneider
- 申请人地址： DEX
- 专利权人： Schering AG
- 当前专利权人： Schering AG
- 当前专利权人地址： DEX
- 优先权： DEX19635525 19960820
- 主分类号： C07J41/00
- IPC分类号： C07J41/00 ; C07J43/00 ; C07J53/00 ; C07D315/00 ; C07J1/00 ; C07J13/00 ; C07J31/00
摘要：
This invention describes new, substituted 7.alpha.-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organic and inorganic acids.The new compounds represent compounds with very strong antiestrogenic action.The compounds according to the invention are, on the one hand, pure antiestrogens, or, on the other hand, antiestrogens with estrogenic partial action. Based on this spectrum of action, the new compounds are highly suitable for the production of pharmaceutical agents for tumor therapy and hormone replacement treatment.
公开/授权文献
- US5487375A Stabilizers adapted to be connected to a bow 公开/授权日：1996-01-30