发明授权
- 专利标题： Serine protease inhibitors
- 专利标题（中）： 丝氨酸蛋白酶抑制剂
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申请号： US90274申请日： 1998-06-03
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公开(公告)号： US6001814A公开(公告)日： 1999-12-14
- 发明人: Albert C. Gyorkos , Lyle W. Spruce
- 申请人： Albert C. Gyorkos , Lyle W. Spruce
- 申请人地址： NJ Bedminster
- 专利权人： Cortech Inc.
- 当前专利权人： Cortech Inc.
- 当前专利权人地址： NJ Bedminster
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07D271/10 ; C07D413/12 ; C07D413/14 ; C07D417/12 ; C07K5/02 ; C07K5/06 ; C07K5/062 ; C07K5/065 ; C07K5/068 ; C07K5/072 ; C07K5/078 ; C07K5/083 ; C07K5/12 ; A61K38/05 ; A61K38/06
摘要：
The present invention relates to certain substituted oxadiazole nonpeptides, which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septic shock and multiple organ failure. A series of studies also have indicated the involvement HNE in myocardial ischemia-reperfusion injury, emphysema. HNE-mediated processes are implicated in other conditions such as arthritis, periodontal disease, glomerulonephritis, dermatitis, psoriasis, cystic fibrosis, chronic bronchitis, atherosclerosis, Alzheimer's disease, organ transplantation, corneal ulcers, and invasion behavior of malignant tumors.
公开/授权文献
- USD410409S Floral display holder 公开/授权日：1999-06-01
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