发明授权
- 专利标题： Bacterial inhibition with an oligosaccharide compound
- 专利标题（中）： 用寡糖化合物进行细菌抑制
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申请号： US54890申请日： 1998-04-03
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公开(公告)号： US6001819A公开(公告)日： 1999-12-14
- 发明人: Paul M. Simon , David Zopf , Roger A. Barthelson , Karl F. Johnson
- 申请人： Paul M. Simon , David Zopf , Roger A. Barthelson , Karl F. Johnson
- 申请人地址： PA Horsham
- 专利权人： Neose Technologies, Inc.
- 当前专利权人： Neose Technologies, Inc.
- 当前专利权人地址： PA Horsham
- 主分类号： C12P19/26
- IPC分类号： C12P19/26 ; A61K9/12 ; A61K31/70 ; A61K31/7008 ; A61K31/7012 ; A61K31/715 ; A61P11/00 ; A61P27/16 ; A61P29/00 ; A61P31/04 ; C07H3/06 ; C07H5/04 ; C07H7/027 ; A01N43/04
摘要：
The present invention is directed to compositions for the treatment of respiratory infections caused by a bacteria selected from the group consisting of S. pneumoniae, H. influenzae, H. parainfluenza, Burkholderia (Pseudomonas) cepacia, and a mixture thereof, comprising a binding inhibiting effective amount of the compound of Formula I, ##STR1## where R.sub.1 is H, (.beta.-1)GalNAc-, SO.sub.3 B (where B is H or a cation) or a sialic acid of Formula II; ##STR2## where R.sub.6, R.sub.7, R.sub.8, and R.sub.10 are each independently H, C.sub.1-6 acyl, lactyl, C.sub.1-6 alkyl, sulfate, phosphate, anhydro, a sialic acid of Formula II, (.alpha.-1)Fuc, (.beta.-1)Glc or (.beta.-1)Gal;R.sub.9 is NH--C.sub.1-6 acyl, glycolylamido, amino or hydroxyl; andA is H or a cation;R.sub.2 is H or (.alpha.-1)Fuc-;R.sub.3 and R.sub.4 are each independently OH or NHAc;R.sub.5 is H, SO.sub.3 B (where B is H or a cation), or a sialic acid of Formula II as defined above; ##STR3## Y is a chemical bond or a linking group; Z is H or a multivalent support;m is 0 or 1; andp is an integer of 1 to 1,000; with the proviso that the compound is not Gal.beta.1-4-GlcNAc.beta.1-3-Gal.beta.1-4-Glc.
公开/授权文献
- USD393620S Bicycle porter 公开/授权日：1998-04-21
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