An airplane fuselage panel including a sheet having peripheral edges routed on routing surfaces, while the sheet is held immobile on a fixture, using a routing end effector carried by a precision computer controlled robot that is directed to the routing surfaces using a digital dataset taken directly from digital engineering part definition records. The sheet has coordination holes drilled while on the fixture using a drilling end effector carried by the precision computer controlled robot that is directed to drilling locations using the digital dataset taken directly from the digital engineering part definition records to accurately locate the hole locations relative to the peripheral edges. The airplane fuselage panel also includes parts, including stringers, stringer clips and shear ties, each having coordination holes drilled by computer controlled drills at locations that will match with corresponding coordination holes in the sheet, so that the parts will be accurately located in positions called for in the digital engineering part definition records when the coordination holes in the parts and the coordination holes in the sheet are aligned and the parts are riveted to the sheet in the accurately located positions.