发明授权
US6008340A Recombinant allergen, fragments thereof, corresponding recombinant DNA
molecules, vectors and hosts containing the DNA molecules
失效
重组变应原，其片段，相应的重组DNA分子，含有DNA分子的载体和宿主
- 专利标题： Recombinant allergen, fragments thereof, corresponding recombinant DNA molecules, vectors and hosts containing the DNA molecules
- 专利标题（中）： 重组变应原，其片段，相应的重组DNA分子，含有DNA分子的载体和宿主
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申请号： US750419申请日： 1997-01-14
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公开(公告)号： US6008340A公开(公告)日： 1999-12-28
- 发明人: Tanja Ball , Susanne Vrtala , Wolfgang Sperr , Peter Valent , Markus Susani , Dietrich Kraft , Rudolf Valenta , Sylvia Laffer
- 申请人： Tanja Ball , Susanne Vrtala , Wolfgang Sperr , Peter Valent , Markus Susani , Dietrich Kraft , Rudolf Valenta , Sylvia Laffer
- 申请人地址： SEX Stockholm
- 专利权人： Pharmacia & Upjohn AB
- 当前专利权人： Pharmacia & Upjohn AB
- 当前专利权人地址： SEX Stockholm
- 优先权： SEX9402089 19940614
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K38/00 ; A61K38/46 ; A61K39/36 ; A61P37/08 ; C07H21/04 ; C07K14/415 ; C12N1/21 ; C12N5/10 ; C12P21/02 ; C07K7/00
摘要：
A recombinant DNA molecule comprising a nucleocide sequence (I) which codes for a polypeptide displaying the antigenicity of one, two or more of the Phl p I epitope clones (28, 34, 41, 42, 43, 50, 52, 64, 80, 85, 86, 95, 97, 98, 103, 108, 109, 113, 114), with the amino acid sequences defined in SEQ ID NOS: 5, 7, 9 and 12-28, and preferably being derived from grasses or monocotyledonic plants, or a nucleotide sequence (II) which hybridizes with such a nucleotide sequence (I) under conditions of high stringency. Polypeptides displaying the antigenicity of one, two or more of the Phl p I epitope clones (28, 34, 41, 42, 43, 50, 52, 64, 80, 85, 86, 95, 97, 98, 103, 108, 109, 113, 114). Recombinant expression vectors containing the recombinant molecule and host cells transformed with the vector. Diagnostic methods based on utilizing the polypeptides in immunoassays for humoral antibodies and cellular reactions.
公开/授权文献
- US5267729A Sorter having a belt guide with a cushion member 公开/授权日：1993-12-07
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