发明授权
US06010905A Method for inducing monocytes to exhibit the phenotype of activated
myeloid dendritic cells
失效
诱导单核细胞表现活化髓样树突状细胞表型的方法
- 专利标题： Method for inducing monocytes to exhibit the phenotype of activated myeloid dendritic cells
- 专利标题（中）： 诱导单核细胞表现活化髓样树突状细胞表型的方法
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申请号： US885671申请日： 1997-06-30
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公开(公告)号： US06010905A公开(公告)日： 2000-01-04
- 发明人: Peter A. Cohen , Brian J. Czerniecki , Gary K. Koski , David E. Weng , Charles Carter , John O. Ojeifo , Gretchen N. Schwartz
- 申请人： Peter A. Cohen , Brian J. Czerniecki , Gary K. Koski , David E. Weng , Charles Carter , John O. Ojeifo , Gretchen N. Schwartz
- 申请人地址： DC Washington
- 专利权人： The United States of America as represented by the Department of Health & Human Services
- 当前专利权人： The United States of America as represented by the Department of Health & Human Services
- 当前专利权人地址： DC Washington
- 主分类号： A61K45/00
- IPC分类号： A61K45/00 ; A61K38/00 ; A61K39/00 ; A61P35/00 ; A61P35/02 ; A61P37/04 ; A61P43/00 ; C12N5/0784 ; C12N5/0786 ; C12N5/09 ; C12N5/08
摘要：
The present invention relates to methods of increasing the antigen presenting ability of monocytes by contacting them with an agent which increases the intracellular calcium level. Methods of obtaining the monocytes are also disclosed. In addition, the present invention relates to methods of inducing bone marrow progenitor cells and endothelial cells to express molecules involved in generating immune responses. Methods of modulating the expression of molecules involved in generating immune responses are also disclosed, as are methods of treating cancer and leukemia.
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