发明授权
US6017954A Method of treating tumors using O-substituted fumagillol derivatives
失效
使用O-取代的烟曲霉醇衍生物治疗肿瘤的方法
- 专利标题： Method of treating tumors using O-substituted fumagillol derivatives
- 专利标题（中）： 使用O-取代的烟曲霉醇衍生物治疗肿瘤的方法
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申请号： US940123申请日： 1992-09-03
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公开(公告)号： US6017954A公开(公告)日： 2000-01-25
- 发明人: Moses J. Folkman , Donald Ingber , Takeshi Fujita
- 申请人： Moses J. Folkman , Donald Ingber , Takeshi Fujita
- 申请人地址： MA Boston
- 专利权人： Children's Medical Center Corp.
- 当前专利权人： Children's Medical Center Corp.
- 当前专利权人地址： MA Boston
- 主分类号： A61K31/335
- IPC分类号： A61K31/335 ; A61K31/336 ; C07D303/22 ; C07D405/14 ; C07D407/14 ; C07D417/14 ; C07D521/00 ; A01N43/20
摘要：
This invention relates to methods of using O-substituted fumagillol derivatives or salts thereof preferably, O-(N-chloroacetylcarbamoyl) fumagillol, O-(N-chloroacetylcarbamoyl)dihydrofumagillol or O-(N-chloracetylcarbamoyl)-6'b-hydroxyfumagillol, which have angiogenesis inhibitory activity, in the treatment and prevention of various diseases caused or advanced by abnormally hyperactive angiogenesis, especially various inflammatory diseases (rheumatism, psoriasis, etc.), diabetic retinopathy and cancer and other angiogenesis-dependent tumors, especially Kaposi's sarcoma, breast cancer, colon cancer.
公开/授权文献
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