Method of treating tumors using O-substituted fumagillol derivatives
    1.
    发明授权
    Method of treating tumors using O-substituted fumagillol derivatives 失效
    使用O-取代的烟曲霉醇衍生物治疗肿瘤的方法

    公开(公告)号:US6017954A

    公开(公告)日:2000-01-25

    申请号:US940123

    申请日:1992-09-03

    摘要: This invention relates to methods of using O-substituted fumagillol derivatives or salts thereof preferably, O-(N-chloroacetylcarbamoyl) fumagillol, O-(N-chloroacetylcarbamoyl)dihydrofumagillol or O-(N-chloracetylcarbamoyl)-6'b-hydroxyfumagillol, which have angiogenesis inhibitory activity, in the treatment and prevention of various diseases caused or advanced by abnormally hyperactive angiogenesis, especially various inflammatory diseases (rheumatism, psoriasis, etc.), diabetic retinopathy and cancer and other angiogenesis-dependent tumors, especially Kaposi's sarcoma, breast cancer, colon cancer.

    摘要翻译: 本发明涉及使用O-取代的烟曲霉醇衍生物或其盐优选O-(N-氯乙酰基氨基甲酰基)烟曲霉醇,O-(N-氯乙酰基氨基甲酰基)二氢烟曲霉素或O-(N-氯乙酰基氨基甲酰基)-6'-羟基烟曲霉素的方法,其中 具有血管生成抑制活性,用于治疗和预防由异常血液生成异常引起或促进的各种疾病,特别是各种炎性疾病(风湿病,牛皮癣等),糖尿病性视网膜病变和癌症以及其它血管生成依赖性肿瘤,特别是卡波西肉瘤,乳腺癌 癌症,结肠癌。

    Member for vehicle and manufacturing process for the same
    4.
    发明授权
    Member for vehicle and manufacturing process for the same 有权
    车辆和制造工艺的成员也是一样的

    公开(公告)号:US09428667B2

    公开(公告)日:2016-08-30

    申请号:US14343332

    申请日:2012-08-27

    摘要: A member for vehicle according to the present invention includes a resinous substrate, and a protective film being formed on a surface of the resinous substrate partially at least. The protective film is made by curing a curing-type coating-agent composition containing: Component (A) (e.g., an isocyanuric ring-containing urethane (meth)acrylate compound) in an amount of from 20 to 80 parts by mass; Component (B) (e.g., an isocyanuric ring-containing tri(meth)acrylate compound free from any urethane bond) in an amount of from 10 to 70 parts by mass; Component (C) (e.g., a reaction product) between a colloidal silica and an alkoxysilane compound having a maleimide group) in amount of from 1 to 35 parts by mass; a radical-polymerization initiator serving as Component (D) in an amount of from 0.1 to 10 parts by mass; an ultraviolet absorber serving as Component (E) in an amount of from 1 to 12 parts by mass; and an organic solvent serving as Component (F) in an amount of from 10 to 1,000 parts by mass; with respect to a sum of the Component (A), the Component (B), and the Component (C) being taken as 100 parts by mass. Said protective film demonstrates excellent wear resistance and weatherability.

    摘要翻译: 根据本发明的车辆用部件包括树脂基板和至少部分地形成在树脂基板的表面上的保护膜。 保护膜通过固化含有20〜80质量份的组分(A)(例如,含异氰脲酸酯环的氨基甲酸酯(甲基)丙烯酸酯化合物))的固化型包衣剂组合物来制备; 组分(B)(例如,不含任何氨基甲酸酯键的含异氰脲酸酯的三(甲基)丙烯酸酯化合物)的量为10〜70质量份; 胶体二氧化硅和具有马来酰亚胺基团的烷氧基硅烷化合物的组分(C)(例如反应产物)的量为1〜35质量份; 作为组分(D)的自由基聚合引发剂的量为0.1至10质量份; 作为组分(E)的紫外线吸收剂的量为1至12质量份; 和作为成分(F)的有机溶剂的量为10〜1000质量份; 相对于成分(A),成分(B)和成分(C)的总和为100质量份。 所述保护膜具有优异的耐磨性和耐候性。

    Nanoporous ceramic composite metal
    5.
    发明授权
    Nanoporous ceramic composite metal 有权
    纳米多孔陶瓷复合金属

    公开(公告)号:US09336958B2

    公开(公告)日:2016-05-10

    申请号:US13995896

    申请日:2011-12-21

    摘要: Since pseudo-capacitance transition metal oxides (for example, MnO2) have high theoretical capacitance and are eco-friendly, inexpensive, and abundant in the natural world, pseudo-capacitance transition metal oxides are gaining attention as promising capacitor electrode materials. However, pseudo-capacitance transition metal oxides have relatively low electronic conductivity and limited charging and discharging rates, and it is therefore difficult to use pseudo capacitance transition metal oxides for high output power applications. If a plating process accompanying a liquid-phase precipitation reaction is performed on a nanoporous metal such as nanoporous gold (NPG) to deposit a ceramic material (for example, MnO2 or SnO2) on the surface of a core metal (for example, NPG), a nanoporous metal-ceramic composite having particular structural characteristics and comprising a metal core part and a ceramic deposition part can be obtained. This hybrid material is a good functional material and exhibits excellent functions when used as an electrode material for high-performance super capacitor (SC) devices or as an electrode material for LIB.

    摘要翻译: 由于假电容过渡金属氧化物(例如MnO 2)具有高的理论电容,并且在自然界中环境友好,价格低廉且丰富,因此假电容过渡金属氧化物作为有希望的电容器电极材料正在受到关注。 然而,伪电容过渡金属氧化物具有相对低的电子导电性和有限的充电和放电速率,因此难以在高输出功率应用中使用伪电容过渡金属氧化物。 如果在纳米多孔金属如纳米多孔金(NPG)上进行伴随液相沉淀反应的电镀工艺,以在核心金属(例如NPG)的表面上沉积陶瓷材料(例如,MnO 2或SnO 2) 可以获得具有特定结构特性并且包括金属芯部分和陶瓷沉积部分的纳米多孔金属 - 陶瓷复合材料。 该混合材料是用作高性能超级电容器(SC)器件的电极材料或用作LIB的电极材料时的功能材料,并且表现出优异的功能。

    Method of manufacturing fused silica crucible
    8.
    发明授权
    Method of manufacturing fused silica crucible 有权
    制造石英坩埚的方法

    公开(公告)号:US08887374B2

    公开(公告)日:2014-11-18

    申请号:US13112580

    申请日:2011-05-20

    摘要: Method of manufacturing a fused silica crucible, including manufacturing a plurality of carbon electrodes for melting a vitreous silica object to be melted by arc discharge by rubbing the surface of a carbon electrode of the electrodes with a vitreous silica of the same type as the vitreous silica object to be melted, by at least one of: inserting a front end of the carbon electrode into a storage tank storing powdered vitreous silica, by at least one of rotating and reciprocating in an axial direction the storage tank and the carbon electrode relative to each other; rubbing the surface of the carbon electrode by ejecting powdered vitreous silica from a nozzle onto the surface of the electrode; rubbing the surface of the electrode with a vitreous silica grinder; and rubbing the surface of the electrode against a rotating surface of a portion of a fused vitreous silica crucible.

    摘要翻译: 石英玻璃坩埚的制造方法,其特征在于,使用与所述玻璃状二氧化硅相同类型的玻璃状二氧化硅摩擦所述电极的碳电极的表面,制造多个用于熔融氧化硅玻璃物体的电弧放电熔化的碳电极 通过以下至少一种方式,通过以下至少一种方式:通过沿着轴向方向旋转和往复运动的方式将碳电极的前端插入储存粉状玻璃状二氧化硅的储存罐中,至少一个相对于每个存储罐和碳电极 其他; 通过将粉末状二氧化硅从喷嘴喷射到电极的表面上来摩擦碳电极的表面; 用石英砂磨机摩擦电极表面; 并且将电极的表面相对于熔融玻璃状石英坩埚的一部分的旋转表面摩擦。

    AUTOMOBILE FRAME COMPONENT
    9.
    发明申请
    AUTOMOBILE FRAME COMPONENT 审中-公开
    汽车框架组件

    公开(公告)号:US20140064831A1

    公开(公告)日:2014-03-06

    申请号:US14004348

    申请日:2012-05-16

    IPC分类号: B62D27/02

    摘要: An automobile frame component includes a closed section constituted by welding a flange portion to a panel part, wherein when a welding position coordinate is represented in a coordinate system in which an end of a contact position between the flange portion and the panel part is assumed as 0, and a flange outer end side of the flange portion is assumed as negative (−) whereas a vertical wall side is assumed as positive (+), and when a radius of a circular arc-like portion connecting a vertical wall portion and the flange portion in the substantially hat-like shape is denoted as R (mm), and a weldable gap amount is denoted as a (mm), a welding position X represented by the following formula is continuously welded using a one-side welding method: +√(2Ra−a2)≧X>1.5 where R≧2.

    摘要翻译: 汽车框架部件包括通过将凸缘部分焊接到面板部件而构成的封闭部分,其中当在将凸缘部分和面板部件之间的接触位置的端部假定为的坐标系中表示焊接位置坐标时 0,凸缘部的凸缘外端侧为负( - ),垂直壁侧为+(+),当连接垂直壁部的圆弧状部的半径与 基本上为帽状的凸缘部分表示为R(mm),可焊接间隙量表示为(mm),由下式表示的焊接位置X使用单面焊接方法连续焊接: +√(2Ra-a2)> = X> 1.5其中R> = 2。