发明授权
US6030967A Naphtholactams and lactones as bone morphogenetic protein active agents
失效
萘酚内酯和内酯作为骨形态发生蛋白活性剂
- 专利标题: Naphtholactams and lactones as bone morphogenetic protein active agents
- 专利标题(中): 萘酚内酯和内酯作为骨形态发生蛋白活性剂
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申请号: US945631申请日: 1997-10-30
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公开(公告)号: US6030967A公开(公告)日: 2000-02-29
- 发明人: Shogo Marui , Masatoshi Hazama , Kohei Notoya , Masaki Ogino
- 申请人: Shogo Marui , Masatoshi Hazama , Kohei Notoya , Masaki Ogino
- 申请人地址: JPX Osaka
- 专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人: Takeda Chemical Industries, Ltd.
- 当前专利权人地址: JPX Osaka
- 优先权: JPX8-218353 19960820; JPX9-107617 19970424
- 主分类号: A61K31/4035
- IPC分类号: A61K31/4035 ; A61K31/4741 ; A61K31/4745 ; C07D209/64 ; C07D209/66 ; C07D317/70 ; C07D401/04 ; C07D405/04 ; C07D471/04 ; C07D491/04 ; C07D491/056 ; A61K31/365 ; A61K31/40 ; C07D217/24 ; C07D317/48
摘要:
A compound of the formula: whereinQ is an optionally substituted carbon atom or N(O)p wherein p is 0 or 1;Y is an optionally substituted methylene group, S(O)q wherein q is an integer of 0 to 2, or an optionally substituted imino group;Z.sup.1 is a C.sub.1-3 alkylene group which may have an oxo group or a thioxo group and may contain etherified oxygen or sulfur within the carbon chain;Z.sup.2 is an optionally substituted C.sub.1-3 alkylene group;Ar is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group;one of R.sup.1 and R.sup.2 is a hydrogen atom, a halogen atom, a hydroxyl group, an optionally substituted lower alkyl group, or an optionally substituted lower alkoxy group;the other is a halogen atom, a hydroxyl group, an optionally substituted lower alkyl group, or an optionally substituted lower alkoxy group; orR.sup.1 and R.sup.2 taken together with adjacent --c.dbd.c-- form a ring; andring A is a benzene ring which may be substituted in addition to R.sup.1 and R.sup.2 ; or a salt thereof.
公开/授权文献
- US5298191A Non-ionic surface active compounds 公开/授权日:1994-03-29
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