发明授权
- 专利标题: Carbapenem derivatives
- 专利标题(中): 卡巴培南衍生物
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申请号: US765387申请日: 1996-12-18
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公开(公告)号: US6037341A公开(公告)日: 2000-03-14
- 发明人: Nobuaki Sato , Manabu Sasho , Atsushi Kamata , Takaaki Suzuki , Isao Sugiyama , Kanemasa Katsu , Takeshi Suzuki
- 申请人: Nobuaki Sato , Manabu Sasho , Atsushi Kamata , Takaaki Suzuki , Isao Sugiyama , Kanemasa Katsu , Takeshi Suzuki
- 申请人地址: JPX Tokyo
- 专利权人: Eisai Co., Ltd.
- 当前专利权人: Eisai Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX6-154055 19940706; JPX7-141832 19950608
- 主分类号: C07D477/00
- IPC分类号: C07D477/00 ; A61K31/397 ; A61K31/40 ; A61K31/445 ; A61P31/04 ; C07D477/20 ; C07D7/18
摘要:
Compounds having potent antimicrobial effects over Gram-positive bacteria and Gram-negative bacteria, a high stability to .beta.-lactamases and DHP-I and a high safety for the human body and a process for producing the same. Carbapenem compounds represented by the following general formula (I) or salts thereof: ##STR1## wherein the ring A represents a 3- to 7-membered non-aromatic ring containing at least one nitrogen atom and optionally having a substituent other than R.sup.6 ; R.sup.1 represents hydrogen or methyl; R.sup.2 and R.sup.5 are the same or different and each represents hydrogen or a protecting group of the hydroxyl group; R.sup.3 represents hydrogen or a protecting group of the carboxyl group; R.sup.4 represents hydrogen, lower alkyl or a protecting group of the amino group; R.sup.6 represents: (1) hydrogen, (2) lower alkyl, optionally substituted by an optionally protected hydroxy, carbamoyl, formimidoyl, acetimidoyl or ##STR2## wherein R.sup.7 and R.sup.8 are the same or different and each represents hydrogen, lower alkyl, or a protecting group of the amino group), or (3) a protecting group of the amino group or a protecting group of the imino group; and m is 0 or 1. These compounds have antimicrobial effects and are useful as a drug.