发明授权
US6037494A Process for the crystallization from a linear or branched (C5-C6)
alcohol or their mixtures of
(S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyy
l)amino]-2,4,6-triiodo-1,3-benzendicarboxamide
失效
由直链或支链(C5-C6)醇或其(S)-N,N'-双[2-羟基-1-(羟甲基)乙基] -5 - [(2-羟基 - 1-氧代丙酰基)氨基] -2,4,6-三碘-1,3-苯二甲酰胺
- 专利标题: Process for the crystallization from a linear or branched (C5-C6) alcohol or their mixtures of (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyy l)amino]-2,4,6-triiodo-1,3-benzendicarboxamide
- 专利标题(中): 由直链或支链(C5-C6)醇或其(S)-N,N'-双[2-羟基-1-(羟甲基)乙基] -5 - [(2-羟基 - 1-氧代丙酰基)氨基] -2,4,6-三碘-1,3-苯二甲酰胺
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申请号: US20424申请日: 1998-02-09
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公开(公告)号: US6037494A公开(公告)日: 2000-03-14
- 发明人: Nicola Desantis
- 申请人: Nicola Desantis
- 申请人地址: NLX
- 专利权人: Bracco International B.V.
- 当前专利权人: Bracco International B.V.
- 当前专利权人地址: NLX
- 优先权: ITXPCT/IB97/00106 19970211
- 主分类号: A61K49/04
- IPC分类号: A61K49/04 ; A61K51/00 ; C07C231/22 ; C07C231/24 ; C07C237/46
摘要:
Disclosed is a new process for the crystallization of (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide (I), using a linear or branched (C5-C6) alcohol or their mixtures.
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