发明授权
- 专利标题： Basic osteoblast growth factor II (bOGF-II)
- 专利标题（中）： 基础成骨细胞生长因子II（bOGF-II）
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申请号： US604965申请日： 1996-02-26
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公开(公告)号： US6046033A公开(公告)日： 2000-04-04
- 发明人: Masaaki Goto , Eisuke Tsuda , Kazuki Yano , Fumie Kobayashi , Kyoji Yamaguchi , Naohiro Washida , Masatsugu Ueda , Tomonori Morinaga , Toshiko Satake , Kanji Higashio
- 申请人： Masaaki Goto , Eisuke Tsuda , Kazuki Yano , Fumie Kobayashi , Kyoji Yamaguchi , Naohiro Washida , Masatsugu Ueda , Tomonori Morinaga , Toshiko Satake , Kanji Higashio
- 申请人地址： JPX Sapporo
- 专利权人： Snow Brand Milk Products Co., Ltd.
- 当前专利权人： Snow Brand Milk Products Co., Ltd.
- 当前专利权人地址： JPX Sapporo
- 优先权： JPX6-168984 19940627
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/51 ; C12N15/12 ; C07K14/475
摘要：
A protein is provided derived from human fibroblast having an N-terminal amino acid sequence represented by SEQ ID NOS: 1 and 2, having a molecular weight of approximately 15kD under reducing and non-reducing conditions by (dosium dodecyl sulfate-polyacrylamide gel electrophoresis), and having an activity to stimulate growth of osteoblast. The protein is produced by gene engineering procedures, contains the amino acid sequence represented by SEQ ID NO: 9 and has osteoblast growth activity. Also provided is a method for preparing the protein by culturing human fibroblast and treating the conditioned medium for purification. The protein is utilized for the treatment of diseases characterized by decreased bone mass such as osteoporosis or is utilized as an antigen for immunological diagnosis of diseases.
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