发明授权
- 专利标题: Prophylactic and therapeutic agent for hepatic diseases
- 专利标题(中): 肝病预防和治疗药物
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申请号: US875759申请日: 1997-08-08
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公开(公告)号: US6048882A公开(公告)日: 2000-04-11
- 发明人: Tatsuya Ohwaki , Masako Yamada , Hiroyuki Yamazaki , Hitoshi Inoue , Yoshiyuki Tahara , Shigeo Kawase
- 申请人: Tatsuya Ohwaki , Masako Yamada , Hiroyuki Yamazaki , Hitoshi Inoue , Yoshiyuki Tahara , Shigeo Kawase
- 申请人地址: JPX Tokyo
- 专利权人: Nisshin Flour Milling Co., Ltd.
- 当前专利权人: Nisshin Flour Milling Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX7-020237 19950208
- 主分类号: C07C211/27
- IPC分类号: C07C211/27 ; C07C211/29 ; C07C215/50 ; C07C217/58 ; C07D213/38 ; C07D307/52 ; C07D317/58 ; C07D317/66 ; C07D333/20 ; A61K31/34 ; A61K31/36
摘要:
Hepatic diseases can be prevented or treated by administering an isoprenylamine derivative represented by the general formula (II) ##STR1## [wherein n represents an integer of 4-12, m represents an integer of 0-3, Ar represents a phenyl group, a furyl group, a thienyl group or a pyridyl group, said group being optionally substituted with one or more of an alkyl group of 1-4 carbon atoms, and alkoxy group of 1-4 carbon atoms, a methylenedioxy group, a hydroxy group or a halogen atom, and R represents a hydrogen atom or an alkyl group of 1-4 carbon atoms] or a pharmacologically acceptable salt thereof at a daily dose of 0.01-500 .mu.g/kg.A lipid emulsion of the compound (II) is particularly useful and can be administered at a remarkably lowered dose as compared with other pharmaceutical preparations.
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