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发明授权
US6048967A Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute 有权
使用硝基氧来避免氧毒性的组合物和方法，特别是用作红细胞替代物的稳定化，聚合，缀合或包封的血红蛋白

Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
摘要：
Compositions and processes to alleviate oxygen toxicity are disclosed based on the addition of nitroxides to physiologically compatible macromolecules. In particular, hemoglobin-based red cell substitutes are describer featuring stable nitroxide free radicals for use in cell-free hemoglobin solutions, encapsulated hemoglobin solutions, stabilized hemoglobin solutions, polymerized hemoglobin solutions, conjugated hemoglobin solutions, nitroxide-labelled albumin, and nitroxide-labelled immunoglobulin. The formulations described herein interact with free radicals, act as antioxidant enzyme-mimics, and alleviate oxidative stress and oxygen-related toxicity.
摘要（中）：

基于向生理上相容的大分子中加入硝基氧而公开了减轻氧气毒性的组合物和方法。 特别地，描述了基于血红蛋白的红细胞替代物，其具有稳定的氮氧自由基，用于无细胞血红蛋白溶液，包封的血红蛋白溶液，稳定的血红蛋白溶液，聚合血红蛋白溶液，共轭血红蛋白溶液，氮氧化物标记的白蛋白和氮氧化物标记 免疫球蛋白。 本文描述的制剂与自由基相互作用，起抗氧化酶 - 模拟物质的作用，并减轻氧化应激和氧相关毒性。

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