发明授权
US6054286A Methods to identify immunomodulators using cognate interaction of
PKC-theta
有权
使用PKC-θ的同源相互作用鉴定免疫调节剂的方法
- 专利标题： Methods to identify immunomodulators using cognate interaction of PKC-theta
- 专利标题（中）： 使用PKC-θ的同源相互作用鉴定免疫调节剂的方法
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申请号： US232130申请日： 1999-01-15
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公开(公告)号： US6054286A公开(公告)日： 2000-04-25
- 发明人: Hugo O. Villar , John Patterson , Anna Voronova , Dorit Ron , Lawrence Kauvar , Gene Napolitano , Nicki Vasquez
- 申请人： Hugo O. Villar , John Patterson , Anna Voronova , Dorit Ron , Lawrence Kauvar , Gene Napolitano , Nicki Vasquez
- 申请人地址： CA South San Francisco
- 专利权人： Telik, Inc.
- 当前专利权人： Telik, Inc.
- 当前专利权人地址： CA South San Francisco
- 主分类号： C12Q1/48
- IPC分类号： C12Q1/48
摘要：
Compounds having immunomodulating activity are identified using a methodology which employs TER14687, TER10311 and/or TER17210 as standards. The effect candidate compounds have on PKC-theta interaction with cognate binding proteins is measured and compared with the standards. The interaction can be measured by a variety of techniques, including assessing translocation of said PKC-theta or fragment. Kits containing the TER14687, TER10311 and/or TER17210 standards are disclosed. TER14687, TER10311 and/or TER17210 are useful in modulating the immune system in a subject by reducing T-cell activity. TER14687, TER10311, TER17210 are used as leads to develop other compounds having immunomodulating activity.
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