发明授权
US6063810A 2-aminoethyl-benzofuran derivatives, preparation thereof and
therapeutical use thereof
失效
2-氨基乙基 - 苯并呋喃衍生物,其制备及其治疗用途
- 专利标题: 2-aminoethyl-benzofuran derivatives, preparation thereof and therapeutical use thereof
- 专利标题(中): 2-氨基乙基 - 苯并呋喃衍生物,其制备及其治疗用途
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申请号: US125947申请日: 1998-08-31
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公开(公告)号: US6063810A公开(公告)日: 2000-05-16
- 发明人: Christophe Philippo , Gilles Courtemanche , Eykmar Fett , Marie Claire Orts , Philippe Bovy , Stephen Eric O'Connor , Anne Marie Galzin
- 申请人: Christophe Philippo , Gilles Courtemanche , Eykmar Fett , Marie Claire Orts , Philippe Bovy , Stephen Eric O'Connor , Anne Marie Galzin
- 申请人地址: FRX Le Plessis Robinson
- 专利权人: Synthelabo
- 当前专利权人: Synthelabo
- 当前专利权人地址: FRX Le Plessis Robinson
- 优先权: FRX9602938 19960308; FRX9610829 19960905
- 主分类号: A61K31/00
- IPC分类号: A61K31/00 ; A61K31/34 ; A61K31/343 ; A61K31/395 ; A61K31/397 ; A61K31/443 ; A61K31/445 ; A61K31/4453 ; A61P1/00 ; A61P9/00 ; A61P9/14 ; A61P11/00 ; A61P11/02 ; A61P25/06 ; C07D307/79 ; C07D307/85 ; C07D307/91 ; C07D405/06
摘要:
Compounds of formula (I), wherein A is a hydrogen atom or a hydroxyl group; B is a hydrogen atom or a C.sub.1-8 alkyl, C.sub.1-8 alkenyl, C.sub.1-8 fluoroalkyl or C.sub.1-8 perfluoroalkyl group; each of R.sub.1, R.sub.2 and R.sub.5, which are the same or different, is a hydrogen atom, a halogen such as chlorine, bromine or fluorine, a C.sub.1-8 alkyl, C.sub.1-8 alkenyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkenyl, C.sub.6, C.sub.10 or C.sub.14 aryl, C.sub.1-6 alkoxycarbonyl, C.sub.1-6 hydroxyalkyl, C.sub.1-6 alkoxyalkyl, C.sub.1-6 alkoxy, C.sub.1-8 fluoroalkyl or C.sub.1-8 perfluoroalkyl group, or R.sub.1 and R.sub.2 taken together form a C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkenyl or C.sub.6, C.sub.10 or C.sub.14 aryl ring, except for compounds in which R.sub.1 and R.sub.2 are both hydrogen; each of R.sub.3 and R.sub.4, which are the same or different, is a hydrogen atom or a C.sub.1-8 alkyl, C.sub.1-8 alkenyl, C.sub.3-8 cycloalkyl or C.sub.3-8 cycloalkenyl group, or R.sub.3 and R.sub.4 taken together form a C.sub.2-6 cycloalkyl or C.sub.3-6 cycloalkenyl ring, e.g., piperidyl, azetidinyl or pyrrolidyl; in the form of enantiomers, diastereoisomers or mixtures thereof, including racemic mixtures;, as well as pharmaceutically acceptable acid addition salts thereof. The compounds may be used in therapy.
公开/授权文献
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