发明授权
US6071935A Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as
farnesyl protein transferase inhibitors
失效
2-(2-氧代 - 亚乙基) - 咪唑烷-4-酮的衍生物及其作为法呢基蛋白转移酶抑制剂的用途
- 专利标题: Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors
- 专利标题(中): 2-(2-氧代 - 亚乙基) - 咪唑烷-4-酮的衍生物及其作为法呢基蛋白转移酶抑制剂的用途
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申请号: US202796申请日: 1999-10-07
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公开(公告)号: US6071935A公开(公告)日: 2000-06-06
- 发明人: Joseph P. Lyssikatos
- 申请人: Joseph P. Lyssikatos
- 申请人地址: NY New York
- 专利权人: Pfizer Inc.
- 当前专利权人: Pfizer Inc.
- 当前专利权人地址: NY New York
- 主分类号: A61K31/00
- IPC分类号: A61K31/00 ; A61K31/44 ; A61K31/4427 ; A61K31/4439 ; A61P35/00 ; A61P43/00 ; C07D401/14 ; A61K31/415
摘要:
The present invention relates to compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of inhibiting abnormal cell growth, including cancer, in a mammal by administering the compounds of formula I to said mammal.
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