发明授权
US6080580A Antisense oligonucleotide modulation of tumor necrosis factor-.alpha.
(TNF-.alpha.) expression
有权
肿瘤坏死因子-α（TNF-α）表达的反义寡核苷酸调控
- 专利标题： Antisense oligonucleotide modulation of tumor necrosis factor-.alpha. (TNF-.alpha.) expression
- 专利标题（中）： 肿瘤坏死因子-α（TNF-α）表达的反义寡核苷酸调控
-
申请号： US166186申请日： 1998-10-05
-
公开(公告)号： US6080580A公开(公告)日： 2000-06-27
- 发明人: Brenda F. Baker , C. Frank Bennett , Madeline M. Butler , William R. Shanahan, Jr.
- 申请人： Brenda F. Baker , C. Frank Bennett , Madeline M. Butler , William R. Shanahan, Jr.
- 申请人地址： CA Carlsbad
- 专利权人： Isis Pharmaceuticals Inc.
- 当前专利权人： Isis Pharmaceuticals Inc.
- 当前专利权人地址： CA Carlsbad
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C12N15/113 ; C07H21/04 ; C12N15/85 ; C12Q1/68
摘要：
Compositions and methods are provided for inhibiting the expression of human tumor necrosis factor-.alpha. (TNF-.alpha.). Antisense oligonucleotides targeted to nucleic acids encoding TNF-.alpha. are preferred. Methods of using these oligonucleotides for inhibition of TNF-.alpha. expression and for treatment of diseases, particularly inflammatory and autoimmune diseases, associated with overexpression of TNF-.alpha. are provided.
公开/授权文献
- US4813250A Lock device with concealed mounting screws 公开/授权日：1989-03-21
信息查询
IPC分类:
