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    EFFICIENT REDUCTION OF TARGET RNA'S BY SINGLE- AND DOUBLE-STRANDED OLIGOMERIC COMPOUNDS
    5.
    发明申请
    EFFICIENT REDUCTION OF TARGET RNA'S BY SINGLE- AND DOUBLE-STRANDED OLIGOMERIC COMPOUNDS 审中-公开
    单链和双链寡聚化合物有效减少目标RNA

    公开(公告)号：US20100041047A1

    公开(公告)日：2010-02-18

    申请号：US12511437

    申请日：2009-07-29

    申请人： Timothy Vickers ,  Seongjoon Koo ,  C. Frank Bennett ,  Stanley T. Crooke ,  Nicholas M. Dean ,  Brenda F. Baker

    发明人： Timothy Vickers ,  Seongjoon Koo ,  C. Frank Bennett ,  Stanley T. Crooke ,  Nicholas M. Dean ,  Brenda F. Baker

    IPC分类号： C12Q1/68 ,  C07H21/02

    CPC分类号： C12N15/1138 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/53 ,  C12N2310/3525

    摘要： The present invention provides, inter alia, methods of selecting a single-stranded oligomeric compounds for inhibiting RNA expression, methods of generating double-stranded oligomeric compounds, methods of identifying optimized double-stranded oligomeric compounds, methods of selecting optimized single-stranded oligomeric compounds, methods of selecting optimized double-stranded oligomeric compounds, methods of identifying multifunctional oligomeric compounds, methods for optimizing target region selection for modulation of RNA expression, methods of optimizing expression modulation of RNA, and the like. The present invention further provides oligomeric compounds, 8-80 nucleobases in length targeted to a target RNA, wherein said oligomeric compound hybridizes to said target RNA and inhibits RNA levels by at least 50% in both single-stranded and double-stranded forms, and multifunctional oligomeric compounds.

    摘要翻译： 本发明尤其提供了选择用于抑制RNA表达的单链寡聚化合物的方法，产生双链寡聚化合物的方法，鉴定优化的双链寡聚化合物的方法，选择优化的单链寡聚化合物的方法 选择优化的双链寡聚化合物的方法，鉴定多功能寡聚化合物的方法，用于优化用于调节RNA表达的靶区选择的方法，优化RNA表达调节的方法等。 本发明进一步提供低聚化合物，长度靶向靶RNA的8-80个核碱基，其中所述寡聚化合物与所述靶RNA杂交并且以单链和双链形式抑制至少50％的RNA水平，以及 多官能寡聚化合物。

    System of components for preparing oligonucleotides
    7.
    发明授权
    System of components for preparing oligonucleotides 失效
    制备寡核苷酸的组分体系

    公开(公告)号：US07321828B2

    公开(公告)日：2008-01-22

    申请号：US09067638

    申请日：1998-04-28

    申请人： Lex M. Cowsert ,  Brenda F. Baker ,  John McNeil ,  Susan M. Freier ,  Henri M. Sasmor ,  Douglas G. Brooks ,  Cara Ohashi ,  Jacqueline R. Wyatt ,  Alexander H. Borchers ,  Timothy A. Vickers

    发明人： Lex M. Cowsert ,  Brenda F. Baker ,  John McNeil ,  Susan M. Freier ,  Henri M. Sasmor ,  Douglas G. Brooks ,  Cara Ohashi ,  Jacqueline R. Wyatt ,  Alexander H. Borchers ,  Timothy A. Vickers

    IPC分类号： C12P19/34 ,  G06F19/00 ,  C12Q1/68

    CPC分类号： C12Q1/6811 ,  B01J2219/007 ,  C12N15/1048 ,  C40B50/02 ,  G06F19/18 ,  G06F19/22

    摘要： Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A “virtual” oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the selected nucleobase sequences is generated. These virtual compounds are reviewed and compounds predicted to have particular properties are selected. The selected compounds are robotically synthesized and are preferably robotically assayed for a desired physical, chemical or biological activity. Active compounds are thus generated and, at the same time, preferred sequences and regions of the target nucleic acid that are amenable to oligonucleotide or sequence-based modulation are identified.

    摘要翻译： 提供了用于产生具有期望的物理，化学和/或生物活性的合成化合物（即活性化合物）的相互优选的基于计算机的迭代方法。 在该过程的迭代过程中，提供或选择靶核酸序列，并且根据确定的标准以计算机生成候选核碱基序列的文库。 选择“虚拟”寡核苷酸化学，并产生具有选定的核碱基序列的虚拟寡核苷酸化合物文库。 审查这些虚拟化合物，并选择预测具有特定性质的化合物。 所选择的化合物是机械合成的，并且优选机械地测定所需的物理，化学或生物活性。 因此产生活性化合物，并且同时确定适用于寡核苷酸或基于序列的调节的靶核酸的优选序列和区域。

    Antisense modulation of interleukin 12 p35 subunit expression
    9.
    发明授权
    Antisense modulation of interleukin 12 p35 subunit expression 有权
    白介素12 p35亚基表达的反义调制

    公开(公告)号：US06399379B1

    公开(公告)日：2002-06-04

    申请号：US09851520

    申请日：2001-05-07

    申请人： Brenda F. Baker ,  Susan M. Freier

    发明人： Brenda F. Baker ,  Susan M. Freier

    IPC分类号： C12Q168

    CPC分类号： C12N15/1136 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

    摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Interleukin 12 p35 subunit. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interleukin 12 p35 subunit. Methods of using these compounds for modulation of Interleukin 12 p35 subunit expression and for treatment of diseases associated with expression of Interleukin 12 p35 subunit are provided.

    摘要翻译： 提供反义化合物，组合物和方法用于调节白细胞介素12p35亚基的表达。 组合物包含靶向编码白细胞介素12p35亚基的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节白介素12p35亚基表达和治疗与白细胞介素12p35亚基表达相关的疾病的方法。