发明授权
- 专利标题: CTLA4/CD28 ligands and uses therefor
- 专利标题(中): CTLA4 / CD28配体及其用途
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申请号: US479744申请日: 1995-06-07
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公开(公告)号: US6084067A公开(公告)日: 2000-07-04
- 发明人: Gordon J. Freeman , Lee M. Nadler , Gary S. Gray
- 申请人: Gordon J. Freeman , Lee M. Nadler , Gary S. Gray
- 申请人地址: MA Boston MA Cambridge
- 专利权人: Dana-Farber Cancer Institute,Genetics Institute, Inc.
- 当前专利权人: Dana-Farber Cancer Institute,Genetics Institute, Inc.
- 当前专利权人地址: MA Boston MA Cambridge
- 优先权: WOXPCT/US94/08423 19940726
- 主分类号: C12N15/09
- IPC分类号: C12N15/09 ; A61K31/00 ; A61K38/00 ; A61K39/395 ; A61P37/00 ; A61P37/08 ; C07K14/705 ; C07K16/28 ; C07K19/00 ; C12N15/12 ; C12N15/85 ; C07K14/47
摘要:
Nucleic acids encoding novel CTLA4/CD28 ligands which costimulate T cell activation are disclosed. In one embodiment, the nucleic acid has a sequence which encodes a B lymphocyte antigen, B7-2. Preferably, the nucleic acid is a DNA molecule comprising at least a portion of a nucleotide sequence shown in FIG. 8, SEQ ID NO:1 or FIG. 14, SEQ ID NO:23. The nucleic acid sequences of the invention can be integrated into various expression vectors, which in turn direct the synthesis of the corresponding proteins or peptides in a variety of hosts, particularly eukaryotic cells, such as mammalian and insect cell culture. Also disclosed are host cells transformed to produce proteins or peptides encoded by the nucleic acid sequences of the invention and isolated proteins and peptides which comprise at least a portion of a novel B lymphocyte antigen. Proteins and peptides described herein can be administered to subjects to enhance or suppress T cell-mediated immune responses.
公开/授权文献
- USD328936S Iron type golf club head 公开/授权日:1992-08-25