发明授权
- 专利标题： Method of synthesizing enriched decaborane for use in generating boron neutron capture therapy pharmaceuticals
- 专利标题（中）： 用于产生硼中子捕获治疗药物的富集的十硼烷的合成方法
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申请号： US842979申请日： 1997-04-24
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公开(公告)号： US6086837A公开(公告)日： 2000-07-11
- 发明人: Robert L. Cowan , Daniel M. Ginosar , Gary B. Dunks
- 申请人： Robert L. Cowan , Daniel M. Ginosar , Gary B. Dunks
- 申请人地址： ID Idaho
- 专利权人： Bechtel BWXT Idaho, LLC
- 当前专利权人： Bechtel BWXT Idaho, LLC
- 当前专利权人地址： ID Idaho
- 主分类号： C01B35/02
- IPC分类号： C01B35/02 ; C01B6/10
摘要：
A method is described for synthesizing decaborane wherein at least about 90% of the boron atoms in the decaborane are the .sup.10 B isotope, comprising the steps of: (a) reacting boric acid with a C.sub.1 to C.sub.10 alkanol to form a .sup.10 B-alkyl borate wherein at least about 90% of the boron atoms in the boric acid are the .sup.10 B isotope; (b) reducing the .sup.10 B-alkyl borate to form an alkali metal .sup.10 B-borohydride; (c) converting the alkali metal .sup.10 B-borohydride to a .sup.10 B-tetradecahydroundecaborate ion; and (d) converting the .sup.10 B-tetradecahydroundecaborate ion to .sup.10 B-decaborane. Methods of preparing tetradecahydroundecaborate ions and decaborane from alkali metal borohydrides are also described.
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