Method of synthesizing enriched decaborane for use in generating boron
neutron capture therapy pharmaceuticals
    1.
    发明授权
    Method of synthesizing enriched decaborane for use in generating boron neutron capture therapy pharmaceuticals 失效
    用于产生硼中子捕获治疗药物的富集的十硼烷的合成方法

    公开(公告)号:US6086837A

    公开(公告)日:2000-07-11

    申请号:US842979

    申请日:1997-04-24

    IPC分类号: C01B35/02 C01B6/10

    CPC分类号: C01B35/026

    摘要: A method is described for synthesizing decaborane wherein at least about 90% of the boron atoms in the decaborane are the .sup.10 B isotope, comprising the steps of: (a) reacting boric acid with a C.sub.1 to C.sub.10 alkanol to form a .sup.10 B-alkyl borate wherein at least about 90% of the boron atoms in the boric acid are the .sup.10 B isotope; (b) reducing the .sup.10 B-alkyl borate to form an alkali metal .sup.10 B-borohydride; (c) converting the alkali metal .sup.10 B-borohydride to a .sup.10 B-tetradecahydroundecaborate ion; and (d) converting the .sup.10 B-tetradecahydroundecaborate ion to .sup.10 B-decaborane. Methods of preparing tetradecahydroundecaborate ions and decaborane from alkali metal borohydrides are also described.

    摘要翻译: 描述了用于合成十硼烷的方法,其中十硼烷中的至少约90%的硼原子是10B同位素,包括以下步骤:(a)使硼酸与C1至C10链烷醇反应以形成10B-烷基硼酸盐,其中 硼酸中至少约90%的硼原子是10B同位素; (b)还原10B-烷基硼酸盐以形成碱金属10B-硼氢化物; (c)将碱金属10B-硼氢化物转化成10B-十四氢十八硼酸根离子; 和(d)将10B-十四氢十八硼酸根离子转化为10B-十硼烷。 还描述了从碱金属硼氢化物制备十四碳代硼酸根离子和十硼烷的方法。

    Synthesis of tetradecahydroundecaborate (-1) from borohydride ion
    7.
    发明授权
    Synthesis of tetradecahydroundecaborate (-1) from borohydride ion 失效
    从硼氢化物离子合成十四氢十硼酸盐({31 1)

    公开(公告)号:US4153672A

    公开(公告)日:1979-05-08

    申请号:US926757

    申请日:1978-07-21

    CPC分类号: C01B35/00

    摘要: The tetradecahydroundecaborate(-1) anion is synthesized from a metal borohydride by heating a suspension of the borohydride ion in a solvent, such as diglyme, with agitation at a temperature of from 85.degree. C. to about 135.degree. C. and adding an alkyl halide. The B.sub.11 H.sub.14.sup.- anion obtained is useful in the synthesis of decaborane, an intermediate in formation a carborane-based polymers.

    摘要翻译: {PG,1]通过在溶剂例如二甘醇二甲醚中加热硼氢化物离子的悬浮液,在85(20℃至约20℃)的温度下,从金属硼氢化合物合成十四氢十硼酸盐({31 1) 135 {20 {0℃并加入烷基卤化物。 B {HD 11 {L H {HD 14 {HU {31 {L阴离子获得可用于合成十硼烷,形成中间体为碳硼烷基聚合物。