发明授权
- 专利标题： Recombinant human anti-FB5 antibodies
- 专利标题（中）： 重组人抗FB5抗体
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申请号： US013872申请日： 1998-01-27
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公开(公告)号： US6090930A公开(公告)日： 2000-07-18
- 发明人: Thomas Paul Wallace , Francis Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
- 申请人： Thomas Paul Wallace , Francis Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
- 申请人地址： NY New York
- 专利权人： Ludwig Institute for Cancer Research
- 当前专利权人： Ludwig Institute for Cancer Research
- 当前专利权人地址： NY New York
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; C12N15/13 ; C07H21/04 ; C12N1/20
摘要：
The invention provides for the production of several humanized murine antibodies specific for the antigen FB5, which is recognized by the murine antibody FB5. The FB5 antigen is expressed on the luminal surface of vascular endothelial cells of a wide range of malignant tumors. The invention also provides for numerous polynucleotide encoding humanized FB5 specific antibodies, expression vectors for producing humanized FB5 specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized FB5 specific antibodies. Additionally, the invention provides methods of treating cancer using FB5 specific antibodies.
公开/授权文献
- US4753025A Sign arrangement 公开/授权日：1988-06-28
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