发明授权
- 专利标题: Method and composition for treating thrombosis
- 专利标题(中): 治疗血栓形成的方法和组成
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申请号: US465498申请日: 1995-06-05
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公开(公告)号: US6100236A公开(公告)日: 2000-08-08
- 发明人: Michael D. Pierschbacher , David S. Lukeman , Soan Cheng , William S. Craig
- 申请人: Michael D. Pierschbacher , David S. Lukeman , Soan Cheng , William S. Craig
- 申请人地址: CA La Jolla
- 专利权人: La Jolla Cancer Research Foundation
- 当前专利权人: La Jolla Cancer Research Foundation
- 当前专利权人地址: CA La Jolla
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; A61P7/02 ; C07K7/00 ; C07K7/06 ; C07K7/54 ; C07K7/64 ; C07K14/00 ; C07K14/705 ; C07K14/745 ; C07K14/75 ; C07K14/78 ; A61K38/08 ; A61K38/12
摘要:
The invention provides RGD containing peptides which are cyclized and contain hydrophobic moieties adjacent the carboxy terminus of the RGD sequence. Such peptides have an high affinity for the receptor IIb/IIIa and low affinity for the fibronectin and vitronectin receptors. Such peptides can be administered in a suitable physiologically acceptable carrier to therapeutically treat thrombosis.
公开/授权文献
- US4480544A High-production rotary offset printing machine 公开/授权日:1984-11-06
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