Invention Grant
US6103751A Carotene analogs of porphyrins, chlorins and bacteriochlorins as
therapeutic and diagnostic agents
失效
卟啉类胡萝卜素类似物，二氢卟酚和细菌毒素作为治疗和诊断剂
- Patent Title: Carotene analogs of porphyrins, chlorins and bacteriochlorins as therapeutic and diagnostic agents
- Patent Title (中): 卟啉类胡萝卜素类似物，二氢卟酚和细菌毒素作为治疗和诊断剂
-
Application No.: US102417Application Date: 1998-06-22
-
Publication No.: US6103751APublication Date: 2000-08-15
- Inventor: Ravindra K. Pandey , William R. Potter , Thomas J. Dougherty
- Applicant: Ravindra K. Pandey , William R. Potter , Thomas J. Dougherty
- Applicant Address: NY Buffalo
- Assignee: Health Research, Inc.
- Current Assignee: Health Research, Inc.
- Current Assignee Address: NY Buffalo
- Main IPC: A61K49/00
- IPC: A61K49/00 ; C07D487/22 ; C07D519/00 ; A61K31/40
Abstract:
A carotene conjugate of the formula: ##STR1## where R.sup.1 is hydrogen or methyl; R.sup.2 is: ##STR2## R.sup.3, R.sup.4 and R.sup.5 are independently, hydrogen, methyl or ethyl; R.sup.6 and R.sup.7 are independently --R.sup.13, --OR , --C(R.sup.6)(O), --C(R.sup.16).sub.2 OR.sup.13, --CH.dbd.CHR.sup.13, or --(CH.sub.2)R.sup.14 ; R.sup.8 is --R.sup.13, --OR.sup.13, --C(R.sup.16)(O), --C(R.sup.16).sub.2 OR.sup.13, --CH.dbd.CHR.sup.13, or --(CH.sub.2)R.sup.14 or taken with R.sup.10 is .dbd.O; R.sup.9 is --R.sup.13, --OR.sup.13, --C(R.sup.16)(O), --C(R.sup.16).sub.2 OR.sup.13, --CH.dbd.CHR.sup.13, or --(CH.sub.2)R.sup.14 or taken with R.sup.10 is a chemical bond; R.sup.10 is --R.sup.13, --OR.sup.13, --C(R.sup.16)(O) , --C(R.sup.16).sub.2 OR.sup.13, --CH.dbd.CHR.sup.13, or --(CH.sub.2)R.sup.14 or taken together with R.sup.9 is a chemical bond or taken with R.sup.8 is .dbd.O; R.sup.11 is R.sup.13, or --OR.sup.13 ; R.sup.12 is --C(R.sup.13).sub.2 C(Y)--, --C(O)O(O)C--, --C(NR.sup.13)O(O)C--, or --C(O)N(R.sup.15)--C(O)--; R.sup.13 is, independently at each occurrence, hydrogen or lower alkyl of from 1 through about 10 carbon atoms; R.sup.14 is an amino acid residue, R.sup.15 is --R.sup.13, --R.sup.14, or --C(O)NHR.sup.13 ; R.sup.16 is, independently at each occurrence, hydrogen or lower alkyl of 1 to about 4 carbon atoms and Y is .dbd.O, .dbd.S, or 2H--.
Public/Granted literature
- US5399436A Electro-sensitive thermal transfer recording medium Public/Granted day:1995-03-21
Information query
