公开(公告)号：US20100144820A1

公开(公告)日：2010-06-10

申请号：US12448661

申请日：2007-09-27

申请人： Ravindra K. Pandey ,  Thomas J. Dougherty ,  William R. Potter

发明人： Ravindra K. Pandey ,  Thomas J. Dougherty ,  William R. Potter

IPC分类号： A61K31/409 ,  C07D487/22 ,  A61P35/00

CPC分类号： A61K31/41 ,  A61K41/0071

摘要： A method for treating cancer and other hyperproliferative tissues in humans that can be exposed to light comprising injection of HPPH at the equivalent to a dose of 0.05 to 0.11 mg/kg of body weight 24 hours post injection and exposing the tumor or other hyperproliferative tissue to 665±10 nm of light at 50 to 200 Joules/cm2.

摘要翻译： 一种用于治疗可暴露于光的人类的癌症和其它过度增生组织的方法，包括以相当于注射后24小时0.05至0.11mg / kg体重的剂量注射HPPH并将肿瘤或其它过度增生组织暴露于 在50至200焦耳/平方厘米的光照下为665±10nm。

公开(公告)号：US07166719B2

公开(公告)日：2007-01-23

申请号：US10607922

申请日：2003-06-27

申请人： Ravindra K. Pandey ,  William R. Potter ,  Thomas J. Dougherty

发明人： Ravindra K. Pandey ,  William R. Potter ,  Thomas J. Dougherty

IPC分类号： C09B47/04

CPC分类号： C07D471/22 ,  A61K41/0071 ,  A61K41/0076 ,  C09B47/00 ,  C09B69/108

摘要： Provided herein are compounds for detection, diagnosis and treatment of target tissues or target compositions, including hyperproliferative tissues such as tumors, using photodynamic methods. In particular, photosensitizer compounds that collect in hyperproliferative tissue are provided. In another embodiment, compounds that absorb light at a wavelength of from about 700 to about 850 nm are provided. In a further embodiment, compounds that are detectable by magnetic resonance imaging are provided.

摘要翻译： 本文提供了使用光动力学方法检测，诊断和治疗靶组织或靶组合物的化合物，包括过度增殖组织如肿瘤。 特别地，提供了在过度增殖组织中收集的光敏剂化合物。 在另一个实施方案中，提供了吸收波长为约700至约850nm的光的化合物。 在另一个实施方案中，提供了可通过磁共振成像检测的化合物。

公开(公告)号：US6084717A

公开(公告)日：2000-07-04

申请号：US368274

申请日：1999-08-03

申请人： Leroy M. Wood ,  William R. Potter

发明人： Leroy M. Wood ,  William R. Potter

IPC分类号： A61B18/20 ,  A61N5/06 ,  G02B27/14 ,  G02B27/10 ,  G02B5/30

CPC分类号： G02B27/106 ,  G02B27/1073 ,  G02B27/144 ,  G02B27/145 ,  A61B2018/2065 ,  A61N5/0601 ,  A61N5/062

摘要： An apparatus that efficiently and accurately splits a laser beam input into eight or more outputs where the beam energies of the output beams are within ten and preferably within five percent of each other. The apparatus includes an arrangement of at least seven beam splitters each of which can split an incident laser beam into two exit beams of equal energy at a particular incident angle. At least some of the splitters have different particular incident angles but the particular incident angle of the first splitter is used as the incident angle for all splitters. The exit beams of the first splitter are directed to second and third splitters that have particular incident angles relatively close to the particular incident angle of the first splitter when compared with the relationship of the particular incident angle of the first splitter to the particular incident angles of the remaining splitters.

摘要翻译： 将输出光束的光束能量在10以内，优选彼此相差5％以内的激光束输入有效且精确地分割成8个以上的输出的装置。 该装置包括至少七个分束器的装置，每个分束器可以将入射激光束以特定的入射角度分成两个等能量的出射光束。 至少一些分离器具有不同的特定入射角，但是第一分离器的特定入射角被用作所有分离器的入射角。 与第一分离器的特定入射角与第一分离器的特定入射角与特定入射角的关系相比，第一分离器的出射光束被引导到具有相对接近第一分束器的特定入射角的特定入射角的第二和第三分束器 剩下的分手。

公开(公告)号：US5952366A

公开(公告)日：1999-09-14

申请号：US102394

申请日：1998-06-22

申请人： Ravindra K. Pandey ,  William R. Potter ,  Thomas J. Dougherty

发明人： Ravindra K. Pandey ,  William R. Potter ,  Thomas J. Dougherty

IPC分类号： C07D487/22 ,  A61K31/409 ,  A61K41/00 ,  A61P35/00 ,  C07D519/00 ,  A61K31/40

CPC分类号： C07D519/00 ,  A61K41/0071

摘要： Compounds having the generic formula: ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are independently alkyl of 3 through about 10 carbon atoms; provided that, R.sup.1 and R.sup.2 together contain at least six carbon atoms. The compounds have utility in photodynamic therapy in treatment of tumors and other diseases. The invention includes a method of treatment by contacting a tumor with the compound and then exposing the tumor to light.

摘要翻译： 具有以下通式的化合物：其中R 1，R 2和R 3独立地为3至约10个碳原子的烷基; 条件是R 1和R 2一起含有至少6个碳原子。 该化合物在光动力疗法中可用于治疗肿瘤和其他疾病。 本发明包括通过使肿瘤与化合物接触然后将肿瘤暴露于光来治疗的方法。

公开(公告)号：US5062431A

公开(公告)日：1991-11-05

申请号：US502447

申请日：1990-03-30

申请人： William R. Potter

发明人： William R. Potter

IPC分类号： A61B5/00 ,  A61N5/06

CPC分类号： A61B5/0059 ,  A61B5/415 ,  A61B5/418 ,  A61N5/0601 ,  A61N5/062

摘要： A method and apparatus for in vivo detection of abnormal tissue in patients by irradiating a diagnostic region simultaneously with at least two wavelengths of incident light, and detecting the resulting fluorescence of normal and abnormal tissue. The patient is provided with a photosensitizer which preferentially collects in abnormal tissue, and beams of light--preferably at about 612 and 632.8 nm--are directed to the diagnostic region. The beams of light are chopped at 90 and 135 Hz, respectively. Fluorescent light from the diagnostic region is then detected, and an electronic signal is generated relating to the intensity of the fluorescence. Because of the chopping of the incident beams, the fluorescent light and the resulting electronic signal area also chopped. The electronic signal is provided as input to phase-locked amplifier circuitry, which differentiates between the contribution to the signal resulting from each of the 612 and 632.8 nm incident beams. A difference signal is provided as output to headphones, and the operator of the apparatus is notified of presence of abnormal tissue by changes in pitch of the difference signal. The source for the light may be lasers or an arc lamp, and there may be three or more incident wavelengths used.

摘要翻译： 一种用于通过与至少两个入射光波长同时照射诊断区域并检测所产生的正常和异常组织的荧光来体内检测患者异常组织的方法和装置。 患者设置有优先收集在异常组织中的光敏剂，并且优选约612和632.8nm的光束被引导到诊断区域。 光束分别以90和135 Hz切割。 然后检测来自诊断区域的荧光，并产生与荧光强度有关的电子信号。 由于入射光束的斩波，荧光灯和由此产生的电子信号区域也被切碎。 电子信号作为输入提供给锁相放大器电路，其区分对由612和632.8nm入射光束中的每一个产生的信号的贡献。 提供差分信号作为耳机的输出，并且通过差异信号的音调的变化来通知设备的操作者异常组织的存在。 光源可以是激光器或弧光灯，并且可以存在三个或更多个入射波长。

公开(公告)号：USRE43274E1

公开(公告)日：2012-03-27

申请号：US12321729

申请日：2009-01-23

申请人： Ravindra K. Pandey ,  William R. Potter ,  Thomas J. Dougherty

发明人： Ravindra K. Pandey ,  William R. Potter ,  Thomas J. Dougherty

IPC分类号： C09B47/04

CPC分类号： C07D471/22 ,  A61K41/0071 ,  A61K41/0076 ,  C09B47/00 ,  C09B69/108

摘要： Provided herein are compounds for detection, diagnosis and treatment of target tissues or target compositions, including hyperproliferative tissues such as tumors, using photodynamic methods. In particular, photosensitizer compounds that collect in hyperproliferative tissue are provided. In another embodiment, compounds that absorb light at a wavelength of from about 700 to about 850 nm are provided. In a further embodiment, compounds that are detectable by magnetic resonance imaging are provided.

摘要翻译： 本文提供了使用光动力学方法检测，诊断和治疗靶组织或靶组合物的化合物，包括过度增殖组织如肿瘤。 特别地，提供了在过度增殖组织中收集的光敏剂化合物。 在另一个实施方案中，提供了吸收波长为约700至约850nm的光的化合物。 在另一个实施方案中，提供了可通过磁共振成像检测的化合物。

公开(公告)号：US06782167B2

公开(公告)日：2004-08-24

申请号：US10145554

申请日：2002-05-14

申请人： Leroy M. Wood ,  William R. Potter

发明人： Leroy M. Wood ,  William R. Potter

IPC分类号： G02B626

CPC分类号： G02B6/2817 ,  A61B2018/208 ,  A61N5/062 ,  G02B6/32 ,  G02B6/3897

摘要： An apparatus that efficiently and accurately directs or splits a non-polarized light beam input from a fiber optic into one, two, four or eight output beams wherein the light beam input is passed through a collimator, the apparatus uses non-polarizing beam splitters and the output beams are coupled to fiber optics using a lens matched to divergence of the beam to direct the beam into the fiber optic and uses an iris diaphragm attenuator to adjust the energy of the output beam prior to its entry into the fiber optic.

摘要翻译： 一种将光纤输入的非偏振光束有效地和准确地引导到一个，两个，四个或八个输出光束中的装置，其中光束输入通过准直仪，该装置使用非偏振分束器， 输出光束使用与光束发散匹配的透镜耦合到光纤，以将光束引导到光纤中，并且使用虹膜光阑衰减器在输入光束进入光纤之前调节输出光束的能量。

公开(公告)号：US5403308A

公开(公告)日：1995-04-04

申请号：US980980

申请日：1992-11-24

申请人： Leroy Wood ,  Donn Boyle ,  William R. Potter

发明人： Leroy Wood ,  Donn Boyle ,  William R. Potter

IPC分类号： A61B5/00 ,  A61B18/22 ,  A61N5/06 ,  G02B6/32 ,  G02B6/36 ,  G02B6/42 ,  G02B23/22 ,  G02B23/24 ,  G02B23/26

CPC分类号： A61B5/0059 ,  A61N5/0601 ,  A61N5/062 ,  G02B23/22 ,  G02B23/2423 ,  G02B23/26 ,  G02B6/32 ,  G02B6/4203 ,  A61B2018/2261 ,  G02B6/325 ,  G02B6/3644

摘要： A submersible lens fiberoptic assembly for PDT treatment includes an optical fiber, a fiber jacket, a ball lens made of zirconia and a housing. This fiberoptic assembly is simple and inexpensive to manufacture, and has a high quality of output light beam. A submersible lens fiberoptic assembly for PDT treatments is also disclosed which uses a hemisphere ball lens for treatment of areas inaccessible to a normal "forward looking" lens.

摘要翻译： 用于PDT处理的潜水透镜光纤组件包括光纤，纤维夹套，由氧化锆制成的球透镜和壳体。 该光纤组件制造简单且便宜，并且具有高质量的输出光束。 还公开了一种用于PDT处理的潜水透镜光纤组件，其使用半球球透镜来处理正常“前视”透镜不能接近的区域。

公开(公告)号：US5190536A

公开(公告)日：1993-03-02

申请号：US839724

申请日：1992-02-19

申请人： Leroy Wood ,  Donn Boyle ,  William R. Potter

发明人： Leroy Wood ,  Donn Boyle ,  William R. Potter

IPC分类号： A61B5/00 ,  A61B18/22 ,  A61N5/06 ,  G02B6/32 ,  G02B6/36 ,  G02B6/42 ,  G02B23/22 ,  G02B23/24 ,  G02B23/26

CPC分类号： A61B5/0059 ,  A61N5/0601 ,  A61N5/062 ,  G02B23/22 ,  G02B23/2423 ,  G02B23/26 ,  G02B6/32 ,  G02B6/4203 ,  A61B2018/2261 ,  G02B6/325 ,  G02B6/3644

摘要： A submersible lens fiberoptic assembly for PDT treatment includes an optical fiber, a fiber jacket, a ball lens made of zirconia and a housing. This fiberoptic assembly is simple and inexpensive to manufacture, and has a high quality of output light beam. A submersible lens fiberoptic assembly for PDT treatments is also disclosed which uses a hemisphere ball lens for treatment of areas inaccessible to a normal "forward looking" lens.

摘要翻译： 用于PDT处理的潜水透镜光纤组件包括光纤，纤维夹套，由氧化锆制成的球透镜和壳体。 该光纤组件制造简单且便宜，并且具有高质量的输出光束。 还公开了一种用于PDT处理的潜水透镜光纤组件，其使用半球球透镜来处理正常“前视”透镜不能接近的区域。

公开(公告)号：US4932934A

公开(公告)日：1990-06-12

申请号：US236603

申请日：1988-08-24

申请人： Thomas J. Dougherty ,  William R. Potter ,  Kenneth R. Weishaupt

发明人： Thomas J. Dougherty ,  William R. Potter ,  Kenneth R. Weishaupt

IPC分类号： A61B5/00 ,  A61K31/40 ,  A61K41/00 ,  A61K49/00 ,  A61K51/00 ,  A61N5/06 ,  A61P35/00 ,  A61P43/00 ,  C07D487/22 ,  C07D519/00 ,  C09B47/00 ,  G02B6/04 ,  G02B6/26 ,  G02B6/42

CPC分类号： A61K31/40 ,  A61B5/411 ,  A61B5/416 ,  A61K41/0071 ,  A61N5/0601 ,  A61N5/062 ,  C07D519/00 ,  G02B6/262 ,  G02B6/4204 ,  A61B5/0071 ,  A61B5/0084 ,  G02B6/4298 ,  Y10S607/901

摘要： To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulfuric acid is cycled through a microporous membrane system to exclude low molecular weight products. In the second method, drugs are synthesized or derived from other pyrrole compounds. The drugs: (1) include two covalently bound groups, each with four rings, some of which are pyrroles such as phlorins, porphyrins, chlorins, substituted pyrroles, substituted chlorins or substituted phlorins, each group being arranged in a ring structure, connected covalently to another group and have a triplet energy state above 37.5 kilocalories per mole; (2) are soluble in water, forming an aggregate of over 10,000 molecular weight in water and have an affinity for each other compared to serum protein such that 10 to 100 percent remain self aggregated in serum protein; and (3) are lipophillic and able to disaggregate and attach to cell plasma, nuclear membrane, mitochondria, lysosomes and tissue. The drug obtained by the first method has an empirical formula of approximately C.sub.68 H.sub.70 N.sub.8 O.sub.11 or C.sub.68 H.sub.66 N.sub.8 O.sub.11 Na.sub.4. Neoplastic tissue retains the drug after it has cleared normal tissues and illumination results in necrosis. Moreover, other photosensitizing materials may be combined with a carrier that enters undesirable tissues and cells of the reticular endothelial system such as macrophages. These photosensitizing materials: (1) must have a triplet energy state above 3.5 kilocalories per mole; (2) cannot be easily oxidized; and (3) not physically quench any required energy state. Preferably, this photosensitizing material should be lipophilic.

摘要翻译： 为了获得肿瘤选择性的光敏药物，可用于肿瘤组织的定位和治疗异常肿瘤组织如肿瘤，使用两种方法之一。 在第一种方法中，血卟啉与乙酸和硫酸的反应产物的水解混合物循环通过微孔膜系统以排除低分子量产物。 在第二种方法中，合成或衍生自其他吡咯化合物的药物。 药物：（1）包括两个共价结合的基团，每个具有四个环，其中一些是吡咯，例如卟啉，卟啉，二氢卟酚，取代的吡咯，取代的二氢卟酚或取代的藜芦烯，每个组排列成环结构，共价连接 到另一组，并具有高于每摩尔37.5千卡的三线态能量状态; （2）可溶于水，与血清蛋白质相比，在水中形成了超过10,000分子量的聚集体，并且与血清蛋白质具有亲和力，使得10％至100％在血清蛋白中保持自我聚集; 和（3）是脂肪性的并且能够分解并附着于细胞血浆，核膜，线粒体，溶酶体和组织。 通过第一种方法获得的药物具有约C68H70N8O11或C68H66N8O11Na4的经验式。 肿瘤组织清除正常组织后保留药物，照明会导致坏死。 此外，其它光敏材料可以与进入网状内皮系统的不希望的组织和细胞如巨噬细胞的载体组合。 这些光敏材料：（1）必须具有每千克3.5千卡以上的三线态能量状态; （2）不易氧化; 和（3）不能物理地淬灭任何所需的能量状态。 优选地，该光敏材料应该是亲脂的。